Medchem Practice Exam: Quiz!
- 1.
Which of the following compounds are derived from eicosanoids?
- A.
Prostaglandins
- B.
Thromboxanes
- C.
Prostacyclin
- D.
Leukotrienes
- E.
All of the above
Correct Answer
E. All of the above -
- 2.
Cell membrane phospholipids are hydrolyzed by __________, resulting in the release of arachidonic acid.
Correct Answer
phospholipase A2 - 3.
Arachidonic acid may be acted on by cyclooxygenase to produce prostanoids/leukotrienes (circle one), or acted on by lipoxygenases to produce prostanoids/leukotrienes (circle one).
- A.
Prostanoids; prostanoids
- B.
Prostanoids; leukotrienes
- C.
Leukotrienes; prostanoids
- D.
Leukotrienes; leukotrienes
Correct Answer
B. Prostanoids; leukotrienes -
- 4.
Which enzyme oxidizes arachidonic acid to produce leukotrienes?
- A.
COX 1
- B.
COX 2
- C.
LOX
- D.
COX 3
Correct Answer
C. LOX -
- 5.
Which prostaglandin exerts a protective effect on gastroduodenal mucosa?
- A.
PGD
- B.
PGI2
- C.
PGE1
- D.
PGF
Correct Answer
C. PGE1 -
- 6.
Leukotriene Modifiers, like Montelukast (Singulair) and Zafirlukast (Accolate), were created to assist in the control of ______________________?
- A.
Gastrointestinal inflammation
- B.
Asthma
- C.
Fever
- D.
Pain
Correct Answer
B. Asthma -
- 7.
Which of the following makes the prostaglandin intermediates unstable?
- A.
Isomerase
- B.
Transferase
- C.
Endoperoxide
- D.
Reductase
Correct Answer
C. Endoperoxide -
- 8.
What part of the CNS do antipyretics work at?
- A.
Medulla
- B.
Pituitary
- C.
Amygdala
- D.
Hypothalamus
Correct Answer
D. Hypothalamus -
- 9.
What is APAP most selective for?
- A.
COX-1
- B.
COX-2
- C.
COX-3
- D.
COX-1 and COX-2
- E.
COX-1 and COX-3
- F.
All of the above
Correct Answer
C. COX-3 -
- 10.
Aspirin's actions on COX-1 prevent ___________of arachidomic acid.
- A.
Phosphorylation
- B.
Peroxidation
- C.
Hydration
- D.
Acetylation
Correct Answer
B. Peroxidation -
- 11.
The toxic metabolite that caused acetanilide and phenacetin to be removed from the US market are derivatives of what molecule?
- A.
Glutathione
- B.
Acetylcysteine
- C.
Acetyliminoquinone
- D.
Aniline
Correct Answer
D. Aniline -
- 12.
N-acetyliminoquinone causes depletion of which hepatic peptide?
- A.
Glucuronide
- B.
Aniline
- C.
Glutathione
- D.
Hydroxyamid
Correct Answer
C. Glutathione -
- 13.
The activity of sulindac is dependent on the stereochemistry of the ________?
- A.
Carbon bond
- B.
Bezylidene bond
- C.
Sulfur bond
- D.
All of the above
Correct Answer
B. Bezylidene bond -
- 14.
The active metabolite of nabumetone, __________ has a similar structure to __________.
- A.
Z propionic acid, Ibuprofen
- B.
Cis-indolic acid, piroxicam
- C.
6MNA, Naproxen
- D.
None of the above
Correct Answer
C. 6MNA, Naproxen -
- 15.
Which of the following has the least anti-inflammatory activity?
- A.
Ibuprofen
- B.
Ketoprofen
- C.
Naproxen
- D.
Ketololac
Correct Answer
D. Ketololac -
- 16.
Piroxicam and Meloxicam are unique in that:
- A.
They are carboxylic acid anti-inflammatories
- B.
They are non-carboxylic acid anti-inflammatories
- C.
They are N-arylanthranillic acid anti-inflammatories
- D.
They are not heteroarylpropionic acid anti-inflammatories
Correct Answer
B. They are non-carboxylic acid anti-inflammatories -
- 17.
At physiologic pH, the__________form of piroxicam predominates.
- A.
Cationic
- B.
Anionic
- C.
Fluorinated
- D.
Chelated
Correct Answer
B. Anionic -
- 18.
What is the only available COX-2 on the market in the United States?
- A.
Vioxx
- B.
Celebrex
- C.
Bextra
- D.
Prexige
Correct Answer
B. Celebrex -
- 19.
What common functional group do the majority of COX-2 inhibitors contain?
- A.
Carboxylic acid
- B.
Sulfone
- C.
Thiol
- D.
P-chlorobenzoyl
- E.
All of the above
Correct Answer
B. Sulfone -
- 20.
Of all the selective COX-2 inhibitors ________________ is the only one that contains a _______________ as a functional group, which distinguishes it from the common COX-2 inhibitor.
- A.
Celebrex, carboxylic acid
- B.
Prexige, sulfone
- C.
Prexige,carboxylic acid
- D.
Vioxx, sulfonamide
- E.
Vioxx, sulfone
Correct Answer
C. Prexige,carboxylic acid -
- 21.
DMARDS exhibit all of the following except
- A.
Effective in the treatment of arthritic disorders
- B.
Typically used along with a NSAID or steroid in combination
- C.
Exhibit activity in standard assays for antiarthritic drugs
- D.
They have a very slow onset of action
Correct Answer
C. Exhibit activity in standard assays for antiarthritic drugs -
- 22.
Which one of these drugs exists in monomeric form
- A.
Aurothioglucose
- B.
Sodium aurothiomalate
- C.
Methotrexate
- D.
Auranofin
Correct Answer
D. Auranofin -
- 23.
In order to make ________ orally available, a phospine ligand was attached to the gold atom.
- A.
Auranofin
- B.
Aurothiomalate
- C.
Aurothioglucose
- D.
None of the above
Correct Answer
A. Auranofin -
- 24.
Sulfasalazine, a prodrug, is metabolized to ___________________ and ___________________ through the degradation of _______________________ by bacteria in the colon.
Correct Answer
sulfapyridine, 5-aminosalicylic acid, azo
sulfapyridine 5-aminosalicylic acid azo
Sulfapyridine 5-aminosalicylic Acid azo - 25.
Identify this structure, the pharmacologically active aspect of Teriflunomide, the metabolite of the prodrug Leflunomide:
Correct Answer
alpha-cyanoenol - 26.
Dihydroorotate dehydrogenase is the rate-limiting enzyme for the synthesis of UMP, which Teriflunomide inhibits. This reaction is concurrent with reduction of Ubiquinone. Circle the correct series of reactions.
- A.
Dihyroorotic acid → uridine concurrent with ubiquinone (-OH) → ubiquinone (=O)
- B.
Dihyroorotic acid → uridine concurrent with ubiquinone (=O) → ubiquinone (-OH)
- C.
Uridine → dihyroorotic acid concurrent with ubiquinone (=O) → ubiquinone (-OH)
- D.
Uridine → dihyroorotic acid concurrent with ubiquinone (-OH) → ubiquinone (=O)
Correct Answer
B. Dihyroorotic acid → uridine concurrent with ubiquinone (=O) → ubiquinone (-OH) -
- 27.
Azathioprine is an analog of which of the following nucleoside?
- A.
Adenine
- B.
Guanine
- C.
Thymine
- D.
Uracil
Correct Answer
A. Adenine -
- 28.
Acute gouty arthritis results from the accumulation of:
- A.
Disodium urate
- B.
Monosodium glutamate
- C.
Monosodium urate
- D.
Uric acid crystal deposits in toes
Correct Answer
C. Monosodium urate -
- 29.
Xanthine oxidase is an enzyme that has dual actions catalyzing the formation of _________________ and _________________.
- A.
Xanthine and Uric Acid
- B.
Uric Acid and hypoxanthine
- C.
Xanthine and adenine
- D.
4.Adenine and Uric Acid
Correct Answer
A. Xanthine and Uric Acid -
- 30.
Colchicine inhibits the deposit of urate crystals by decreasing the production of lactic acid causing a/an __________ in pH.
- A.
Increase
- B.
Decrease
- C.
No change
Correct Answer
A. Increase -
- 31.
Sulfinpyrazone is strongly/weakly acidic. Its main metabolites has __________ attached to its acidic carbon.
- A.
Hydrogen
- B.
Methyl
- C.
Glucoronide
Correct Answer
C. Glucoronide -
- 32.
Allopurinol inhibits Xanthine oxidase decreasing uric acid formation and causing an increase in ___________ and __________ which are converted to closely related purine adenosine and guanosine.
Correct Answer
hypoxanthine, xanthine
hypoxanthine xanthine - 33.
Histamine contains which of the following?
- A.
Benzene ring
- B.
Imidazole ring
- C.
Enol functionality
- D.
Methyl substituent
Correct Answer
B. Imidazole ring -
- 34.
Histamine is synthesized in the golgi apparatus of mast cells and basophils by enzymatic ____________of histidine.
Correct Answer
decarboxylation - 35.
In aqueous solution, the π/τ hydrogen form of histamine predominates, but as a solid the π/τ hydrogen is found. Circle the correct answers.
- A.
π; π
- B.
Ï€; Ï„
- C.
τ; π
- D.
Ï„; Ï„
Correct Answer
C. τ; π -
- 36.
What is the core structure in both chromolyn and nedochromil?
- A.
Kellin
- B.
Chromene
- C.
Benzofuan
- D.
Benzene
Correct Answer
B. Chromene -
- 37.
This spacer usually consists of:
- A.
4 or 5 carbons in length, a 5 membered ring, branched, saturated or unsaturated
- B.
2 or 3 carbons in length, a 5 membered ring, branched, saturated or unsaturated
- C.
4 or 5 carbons in length, some ring structure, branched, saturated or unsaturated
- D.
2 or 3 carbons in length, some ring structure, branched, saturated or unsaturated
Correct Answer
D. 2 or 3 carbons in length, some ring structure, branched, saturated or unsaturated -
- 38.
Match the constituents to their parent name. A = Alkyl amines; B = Ethanolamine ethers; C = Ethylenediamines I II III
- A.
I-A, II-B, III-C
- B.
I-C, II-B, III-A
- C.
I-B, II-C, III-A
- D.
I-C, II- A, III-B
Correct Answer
B. I-C, II-B, III-A -
- 39.
Is the active metabolite of hydroxazine which is also classified as a --------- antihistamine, it is ------- in nature.
- A.
Pheniramine, 1st generation, acidic
- B.
Doxylamine, 2nd generation, basic
- C.
Certirizine, 2nd generation, acidic
- D.
Certirazine, 2nd generation, amphoteric
- E.
Certirizine, 1st generation, basic
Correct Answer
D. Certirazine, 2nd generation, amphoteric -
- 40.
The significant toxicities of Antergen, an ethylenedione ,are associated with the _______.
- A.
Methyl group
- B.
Tertiary nitrogen group
- C.
Aniline group
- D.
Butyl group
Correct Answer
C. Aniline group -
- 41.
Which class of 1st generation antihistamines displayed a lower incidence of sedating side effects with increased duration of action?
- A.
Ethanolamine ether
- B.
Ethylenediamines
- C.
Ring halogenated alkyl amines
Correct Answer
C. Ring halogenated alkyl amines -
- 42.
What is the R group in the active metabolite of Terfenadine:
- A.
CH3
- B.
CH2OH
- C.
CH3CH3
- D.
CO2H
- E.
None of the above
Correct Answer
D. CO2H -
- 43.
The second-generation antihistamines have improved____________ selectivity:
- A.
H1
- B.
H2
- C.
H3
- D.
H4
- E.
H5
Correct Answer
A. H1 -
- 44.
Which of these is the acid metabolite of Hydroxyzine:
- A.
Loratadine
- B.
Terfenadine
- C.
Ceterizin
- D.
Fexofenadine
- E.
Ketotifen
Correct Answer
C. Ceterizin -
- 45.
On the molecule Cimetidine, the N-cyanoguanidine substiuient is:
- A.
Non-polar, non-basic
- B.
Non-polar, basic
- C.
Polar, non-basic
- D.
Polar, basic
Correct Answer
C. Polar, non-basic -
- 46.
The C-5 methyl group on cimetidine affords the molecules;
- A.
Potency
- B.
Decreased bascity
- C.
Selectivity
Correct Answer
C. Selectivity -
- 47.
When assigning stereochemistry for the drug omeprazole, which substituent is given the lowest priority?
- A.
The O
- B.
CH2 adjacent to the sulfur on the right
- C.
The purine ring to the left of the sulfur
- D.
The lone pair off of the sulfur
Correct Answer
D. The lone pair off of the sulfur -
- 48.
Match the following R groups to the corresponding structures: A = Epinephrine (EPI); B = Isoproterenol; C = Norepinephrine (NE)
- A.
I-A, II-B, III-C
- B.
I-B, II-C, III-A
- C.
I-C, II-A, III-B
- D.
I-C, II-B, II-A
Correct Answer
C. I-C, II-A, III-B -
- 49.
Substituents on the alpha-carbon (R2), besides hydrogen, increases the duration of action because the compound is resistant to metabolism by which enzyme?
- A.
Alcohol dehydrogenase
- B.
COMT
- C.
MOA
- D.
Phosphodiesterase
Correct Answer
C. MOA -
- 50.
If the substituent is __________ there is selectivity for the beta-2 receptor, which is enhanced by a bulky N-substituent.
- A.
Methyl
- B.
Ethyl
- C.
Hydrogen
- D.
Benzyl
Correct Answer
B. Ethyl -
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