Medchem Practice Exam: Quiz!

74 Questions | Total Attempts: 104

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Medchem Practice Exam: Quiz!

Questions and Answers
  • 1. 
    Which of the following compounds are derived from eicosanoids?
    • A. 

      Prostaglandins

    • B. 

      Thromboxanes

    • C. 

      Prostacyclin

    • D. 

      Leukotrienes

    • E. 

      All of the above

  • 2. 
    Cell membrane phospholipids are hydrolyzed by __________, resulting in the release of arachidonic acid.
  • 3. 
    Arachidonic acid may be acted on by cyclooxygenase to produce prostanoids/leukotrienes (circle one), or acted on by lipoxygenases to produce prostanoids/leukotrienes (circle one).
    • A. 

      Prostanoids; prostanoids

    • B. 

      Prostanoids; leukotrienes

    • C. 

      Leukotrienes; prostanoids

    • D. 

      Leukotrienes; leukotrienes

  • 4. 
    Which enzyme oxidizes arachidonic acid to produce leukotrienes?
    • A. 

      COX 1

    • B. 

      COX 2

    • C. 

      LOX

    • D. 

      COX 3

  • 5. 
    Which prostaglandin exerts a protective effect on gastroduodenal mucosa?
    • A. 

      PGD

    • B. 

      PGI2

    • C. 

      PGE1

    • D. 

      PGF

  • 6. 
    Leukotriene Modifiers, like Montelukast (Singulair) and Zafirlukast (Accolate), were created to assist in the control of ______________________?
    • A. 

      Gastrointestinal inflammation

    • B. 

      Asthma

    • C. 

      Fever

    • D. 

      Pain

  • 7. 
    Which of the following makes the prostaglandin intermediates unstable?
    • A. 

      Isomerase

    • B. 

      Transferase

    • C. 

      Endoperoxide

    • D. 

      Reductase

  • 8. 
    What part of the CNS do antipyretics work at?
    • A. 

      Medulla

    • B. 

      Pituitary

    • C. 

      Amygdala

    • D. 

      Hypothalamus

  • 9. 
    What is APAP most selective for?
    • A. 

      COX-1

    • B. 

      COX-2

    • C. 

      COX-3

    • D. 

      COX-1 and COX-2

    • E. 

      COX-1 and COX-3

    • F. 

      All of the above

  • 10. 
    Aspirin's actions on COX-1 prevent ___________of arachidomic acid.
    • A. 

      Phosphorylation

    • B. 

      Peroxidation

    • C. 

      Hydration

    • D. 

      Acetylation

  • 11. 
    The toxic metabolite that caused acetanilide and phenacetin to be removed from the US market are derivatives of what molecule?
    • A. 

      Glutathione

    • B. 

      Acetylcysteine

    • C. 

      Acetyliminoquinone

    • D. 

      Aniline

  • 12. 
    N-acetyliminoquinone causes depletion of which hepatic peptide?
    • A. 

      Glucuronide

    • B. 

      Aniline

    • C. 

      Glutathione

    • D. 

      Hydroxyamid

  • 13. 
    The activity of sulindac is dependent on the stereochemistry of the ________?
    • A. 

      Carbon bond

    • B. 

      Bezylidene bond

    • C. 

      Sulfur bond

    • D. 

      All of the above

  • 14. 
    The active metabolite of nabumetone, __________ has a similar structure to __________.
    • A. 

      Z propionic acid, Ibuprofen

    • B. 

      Cis-indolic acid, piroxicam

    • C. 

      6MNA, Naproxen

    • D. 

      None of the above

  • 15. 
    Which of the following has the least anti-inflammatory activity?
    • A. 

      Ibuprofen

    • B. 

      Ketoprofen

    • C. 

      Naproxen

    • D. 

      Ketololac

  • 16. 
    Piroxicam and Meloxicam are unique in that:
    • A. 

      They are carboxylic acid anti-inflammatories

    • B. 

      They are non-carboxylic acid anti-inflammatories

    • C. 

      They are N-arylanthranillic acid anti-inflammatories

    • D. 

      They are not heteroarylpropionic acid anti-inflammatories

  • 17. 
    At physiologic pH, the__________form of piroxicam predominates.
    • A. 

      Cationic

    • B. 

      Anionic

    • C. 

      Fluorinated

    • D. 

      Chelated

  • 18. 
    What is the only available COX-2 on the market in the United States?
    • A. 

      Vioxx

    • B. 

      Celebrex

    • C. 

      Bextra

    • D. 

      Prexige

  • 19. 
    What common functional group do the majority of COX-2 inhibitors contain?
    • A. 

      Carboxylic acid

    • B. 

      Sulfone

    • C. 

      Thiol

    • D. 

      P-chlorobenzoyl

    • E. 

      All of the above

  • 20. 
    Of all the selective COX-2 inhibitors ________________ is the only one that contains a _______________ as a functional group, which distinguishes it from the common COX-2 inhibitor.
    • A. 

      Celebrex, carboxylic acid

    • B. 

      Prexige, sulfone

    • C. 

      Prexige,carboxylic acid

    • D. 

      Vioxx, sulfonamide

    • E. 

      Vioxx, sulfone

  • 21. 
    DMARDS exhibit all of the following except
    • A. 

      Effective in the treatment of arthritic disorders

    • B. 

      Typically used along with a NSAID or steroid in combination

    • C. 

      Exhibit activity in standard assays for antiarthritic drugs

    • D. 

      They have a very slow onset of action

  • 22. 
    Which one of these drugs exists in monomeric form
    • A. 

      Aurothioglucose

    • B. 

      Sodium aurothiomalate

    • C. 

      Methotrexate

    • D. 

      Auranofin

  • 23. 
    In order to make ________ orally available, a phospine ligand was attached to the gold atom.
    • A. 

      Auranofin

    • B. 

      Aurothiomalate

    • C. 

      Aurothioglucose

    • D. 

      None of the above

  • 24. 
    Sulfasalazine, a prodrug, is metabolized to ___________________ and ___________________ through the degradation of _______________________ by bacteria in the colon.
  • 25. 
    Identify this structure, the pharmacologically active aspect of Teriflunomide, the metabolite of the prodrug Leflunomide:
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