Medchem Practice Exam: Quiz!
- 1.Which of the following compounds are derived from eicosanoids?
- A.
Prostaglandins
- B.
Thromboxanes
- C.
Prostacyclin
- D.
Leukotrienes
- E.
All of the above
- 2.Cell membrane phospholipids are hydrolyzed by __________, resulting in the release of arachidonic acid.
- 3.Arachidonic acid may be acted on by cyclooxygenase to produce prostanoids/leukotrienes (circle one), or acted on by lipoxygenases to produce prostanoids/leukotrienes (circle one).
- A.
Prostanoids; prostanoids
- B.
Prostanoids; leukotrienes
- C.
Leukotrienes; prostanoids
- D.
Leukotrienes; leukotrienes
- 4.Which enzyme oxidizes arachidonic acid to produce leukotrienes?
- A.
COX 1
- B.
COX 2
- C.
LOX
- D.
COX 3
- 5.Which prostaglandin exerts a protective effect on gastroduodenal mucosa?
- A.
PGD
- B.
PGI2
- C.
PGE1
- D.
PGF
- 6.Leukotriene Modifiers, like Montelukast (Singulair) and Zafirlukast (Accolate), were created to assist in the control of ______________________?
- A.
Gastrointestinal inflammation
- B.
Asthma
- C.
Fever
- D.
Pain
- 7.Which of the following makes the prostaglandin intermediates unstable?
- A.
Isomerase
- B.
Transferase
- C.
Endoperoxide
- D.
Reductase
- 8.What part of the CNS do antipyretics work at?
- A.
Medulla
- B.
Pituitary
- C.
Amygdala
- D.
Hypothalamus
- 9.What is APAP most selective for?
- A.
COX-1
- B.
COX-2
- C.
COX-3
- D.
COX-1 and COX-2
- E.
COX-1 and COX-3
- F.
All of the above
- 10.Aspirin's actions on COX-1 prevent ___________of arachidomic acid.
- A.
Phosphorylation
- B.
Peroxidation
- C.
Hydration
- D.
Acetylation
- 11.The toxic metabolite that caused acetanilide and phenacetin to be removed from the US market are derivatives of what molecule?
- A.
Glutathione
- B.
Acetylcysteine
- C.
Acetyliminoquinone
- D.
Aniline
- 12.N-acetyliminoquinone causes depletion of which hepatic peptide?
- A.
Glucuronide
- B.
Aniline
- C.
Glutathione
- D.
Hydroxyamid
- 13.The activity of sulindac is dependent on the stereochemistry of the ________?
- A.
Carbon bond
- B.
Bezylidene bond
- C.
Sulfur bond
- D.
All of the above
- 14.The active metabolite of nabumetone, __________ has a similar structure to __________.
- A.
Z propionic acid, Ibuprofen
- B.
Cis-indolic acid, piroxicam
- C.
6MNA, Naproxen
- D.
None of the above
- 15.Which of the following has the least anti-inflammatory activity?
- A.
Ibuprofen
- B.
Ketoprofen
- C.
Naproxen
- D.
Ketololac
- 16.Piroxicam and Meloxicam are unique in that:
- A.
They are carboxylic acid anti-inflammatories
- B.
They are non-carboxylic acid anti-inflammatories
- C.
They are N-arylanthranillic acid anti-inflammatories
- D.
They are not heteroarylpropionic acid anti-inflammatories
- 17.At physiologic pH, the__________form of piroxicam predominates.
- A.
Cationic
- B.
Anionic
- C.
Fluorinated
- D.
Chelated
- 18.What is the only available COX-2 on the market in the United States?
- A.
Vioxx
- B.
Celebrex
- C.
Bextra
- D.
Prexige
- 19.What common functional group do the majority of COX-2 inhibitors contain?
- A.
Carboxylic acid
- B.
Sulfone
- C.
Thiol
- D.
P-chlorobenzoyl
- E.
All of the above
- 20.Of all the selective COX-2 inhibitors ________________ is the only one that contains a _______________ as a functional group, which distinguishes it from the common COX-2 inhibitor.
- A.
Celebrex, carboxylic acid
- B.
Prexige, sulfone
- C.
Prexige,carboxylic acid
- D.
Vioxx, sulfonamide
- E.
Vioxx, sulfone
- 21.DMARDS exhibit all of the following except
- A.
Effective in the treatment of arthritic disorders
- B.
Typically used along with a NSAID or steroid in combination
- C.
Exhibit activity in standard assays for antiarthritic drugs
- D.
They have a very slow onset of action
- 22.Which one of these drugs exists in monomeric form
- A.
Aurothioglucose
- B.
Sodium aurothiomalate
- C.
Methotrexate
- D.
Auranofin
- 23.In order to make ________ orally available, a phospine ligand was attached to the gold atom.
- A.
Auranofin
- B.
Aurothiomalate
- C.
Aurothioglucose
- D.
None of the above
- 24.Sulfasalazine, a prodrug, is metabolized to ___________________ and ___________________ through the degradation of _______________________ by bacteria in the colon.
- 25.
Identify this structure, the pharmacologically active aspect of Teriflunomide, the metabolite of the prodrug Leflunomide:
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