Chemistry Exam: Hardest Trivia Quiz To Take!

13 Questions | By Pionkg | Last updated: Mar 20, 2022 | Total Attempts: 101

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Chemistry Exam: Hardest Trivia Quiz To Take! - Quiz

This is a Chemistry Exam and is Hardest Trivia Quiz to take if you have not studied effectively. Do you think you have what it takes to tackle it based on what you know or do you need a refresher? Well, what better way to know than to take the actual test? Press the start button and answer as best as you can.

Questions and Answers

1.

Acetylcholinesterase is responsible for
- A.
  
  Synthesis of choline
- B.
  
  Hydrolysis of ACh
- C.
  
  Acetylation of Choline
2.

To which of the following classes of pharmacological receptors do nicotinic receptors belong?
- A.
  
  1-transmembrane protiens (enzyme associated)
- B.
  
  G-protien coupled
- C.
  
  Ion Channel
- D.
  
  Transcriptional regulators
3.

The rate limiting stop in the hydrolysis of Ach is
- A.
  
  Hydrolysis of the acetylated enzyme
- B.
  
  Diffusion of choline from the active site
- C.
  
  Formation of the acetylated enzyme
- D.
  
  Binding of ACh to the enzyme to form the transition state
4.

Which of the following modifications of Ach results in a potent agonist with muscarinic and nicotinic activity?
- A.
  
  Increase the ethylene bridge by one atom
- B.
  
  Addition of beta methyl on ethylene bridge
- C.
  
  Replacement of one N-mehtyl with N-ethyl
- D.
  
  Replacement of the ester with carbamate
- E.
  
  Addition of alpha methyl on ethylene bridge
5.

Which of the following modification of Ach results in a selective agonist on muscarinic recpetors?
- A.
  
  Replacement of one N-methyl with N-ethyl
- B.
  
  Replacement of the esters with a carbamate
- C.
  
  Addition of alpha methyl on ethylene bridge
- D.
  
  Increase the ethylene bridge by one atom
- E.
  
  Addition of beta methyl on ethylene bridge
6.

Which of the following is the rate-limiting substrate in the synthesis of Ach?
- A.
  
  Choline
- B.
  
  Serine
- C.
  
  S-adenosyl methione
- D.
  
  Acetyl-S-CoA
7.

Choline acetyletransferase is responsible for
- A.
  
  Hydrolysis of ACh
- B.
  
  Synthesis of ACh
- C.
  
  Synthesis of choline
8.

Malathione is considered to have selective toxicity to insects compared to humans. The increased toxicity to insects is due to their inability to metabolize it by:
- A.
  
  Oxidation (replace S with O)
- B.
  
  Hydrolysis with phosphatases
- C.
  
  Hydrolysis of esters
9.

Malathione is considered to have selective toxicity to insects compared to humans. The decreased toxicity in humans is due to:
- A.
  
  Phosphatase (hydrolyze P-S bond)
- B.
  
  Oxidation (replace S with O)
- C.
  
  Carboxyesterase (hydrolyze ester)
10.

Sarin is a chemical warfare agent. The major concern with its use is:
- A.
  
  Only one aging reaction occurs before AChE becomes completely refractory to reactivation.
- B.
  
  AChE cannot be reactivated with pralidoxime
- C.
  
  It is more lipophilic than other agents so more topical absorption occurs
11.

Which of the following compounds used in the treatment of Alzheimer’s disease is not a AChEI?
- A.
  
  Donepezil
- B.
  
  Galantamine
- C.
  
  Memantine
- D.
  
  Rivastigmine
12.

Which of the compounds shown would have the lowest affinity for AChE (largest Ki value)?
- A.
  
  A
- B.
  
  B
- C.
  
  C
- D.
  
  D
13.

Which of the following is false for nicotinic receptors?
- A.
  
  The receptors in the NMJ have two binding sites of Ach
- B.
  
  Thy are voltage regulated ion channels
- C.
  
  They are contained on glycoprotiens imbedded in synaptic membranes
- D.
  
  The SAR for ligands differs for the receptors in the NMJ and the ganglia
- E.
  
  The receptors in the NMJ have a pentameric structure