Kpc Carbapenems

6 Questions | Total Attempts: 47

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Kpc Carbapenems

This quiz deals with the KPC group of carbapenems, the Modified Hodge Test and CLSI recommendations.


Questions and Answers
  • 1. 
    Carbapenems may be hydrolyzed by multiple mechanisms and by organisms other than K. pneumoniae.  Check all examples which apply.
    • A. 

      ESBL (CTX-M) variant + reduced permeability of the cell membrane.

    • B. 

      Upregulated AmpC production + reduced permeability

    • C. 

      Intrinsic chromosomal resistance in certain organisms

    • D. 

      Various carbapenemases found in class A, B and D.

  • 2. 
    Choose the feature below which will help you detect a KPC.
    • A. 

      All carbapenems are resistant.

    • B. 

      Ertapenem is resistant but imipenem appears sensitive.

    • C. 

      Carbapenems appear sensitive but are ineffective in vivo.

    • D. 

      Ertapenem appears more resistant than imipenem.

  • 3. 
    In which state do you find the greatest number of cases of KPC?
  • 4. 
    New CLSI criteria for KPCs suggest that for organisms which are resistant to the cephalosporins, the MIC for carbapenems be no larger than _____ ug/mL.
  • 5. 
    This is a Modified Hodge Test.  Identify the isolate at the far left as Positive or Negative.
  • 6. 
    Which carbapenem disk can be used to perform the Modied Hodge Test?
    • A. 

      Imipenem

    • B. 

      Ertapenem

    • C. 

      Meropenem

    • D. 

      All can be used with equal accuracy