Epilepsy Moa

12 Questions

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Epilepsy Quizzes & Trivia

All of the AEDs should be tested except: Gabapentin, pregabalin and Levetiracetam because their MOAs are unknown. I also left out oxcarbamazipine and fosphenytoin because they have the same MOA as their related drug.


Questions and Answers
  • 1. 
    What is the MOA of Carbamazipine?
    • A. 

      Enhance inactivation of fast Na channels

    • B. 

      Enhance inactivation of slow Na channels

    • C. 

      Open K+ channels

    • D. 

      Weak CAI

    • E. 

      Block T-type Ca channels

  • 2. 
    What is the MOA of lacosamide? 
    • A. 

      Block T-type Ca channels

    • B. 

      Block GABA re-uptake in the presynaptic neuron

    • C. 

      Enhance inactivation of fast Na channels

    • D. 

      Increases GABA mediated Cl influx

    • E. 

      Opens K+ channels

    • F. 

      Enhance inactivation of slow Na channels

  • 3. 
    What is the MOA of Phenytoin? 
    • A. 

      Block GABA re-uptake in the presynaptic neuron

    • B. 

      Enhance inactivation of slow Na channels

    • C. 

      Opens K+ channels

    • D. 

      Enhance inactivation of fast Na channels

    • E. 

      Weak CAI

    • F. 

      Decrease glutamate and aspartate release

  • 4. 
    What is the MOA of Ezogabine? 
    • A. 

      Weak CAI

    • B. 

      Enhance inactivation of slow Na channels

    • C. 

      Block GABA re-uptake in the presynaptic neuron

    • D. 

      Opens K+ channels

    • E. 

      Inhibits Ca channels

    • F. 

      Delays repetitive firing of neurons

  • 5. 
    What is the MOA of lamotrigine? 
    • A. 

      Decreases glutamate and aspartate release

    • B. 

      Increases GABA mediated Cl influx

    • C. 

      Inhibits Ca channels

    • D. 

      Opens K+ channels

    • E. 

      Enhances inactivation of fast Na channels

    • F. 

      Delays repetitive firing of neurons

  • 6. 
    What is the MOA of ethosuximide? 
    • A. 

      Enhance inactivation of fast Na channels

    • B. 

      Block T-type Ca currents

    • C. 

      Opens K+ channels

    • D. 

      Increases GABA mediated Cl influx

    • E. 

      Weak CAI

  • 7. 
    What is the MOA of zonisamide? 
    • A. 

      Enhances inactivation of slow Na channels

    • B. 

      Weak CAI

    • C. 

      Block GABA re-uptake in the presynaptic neuron

    • D. 

      Opens K+ channels

    • E. 

      Blocks T-type Ca currents

    • F. 

      Decreases glutamate and aspartate release

    • G. 

      Enhances inactivation of fast Na channels

    • H. 

      Antagonizes AMPA/kainate activity

  • 8. 
    What is the MOA of Rufinamide? 
    • A. 

      Blocks T-type Ca currents

    • B. 

      Opens K+ channels

    • C. 

      Enhances inactivation of fast Na channels

    • D. 

      Weak CAI

    • E. 

      Increases GABA mediated Cl influx

    • F. 

      Enhances inactivation of slow Na channels

    • G. 

      Increase GABA production

  • 9. 
    What is the MOA of phenobarbital?
    • A. 

      Enhance inactivation of fast Na channels

    • B. 

      Increases GABA mediated Cl influx

    • C. 

      Block GABA re-uptake in the presynaptic neuron

    • D. 

      Weak CAI

    • E. 

      Delays repetitive firing of neurons

    • F. 

      Antagonizes AMPA/kainate activity

    • G. 

      Increase GABA production

  • 10. 
    What is the MOA of topiramate? 
    • A. 

      Antagonizes AMPA/kainate activity

    • B. 

      Enhances inactivation of fast Na channels

    • C. 

      Enhance GABA activity

    • D. 

      Enhances inactivation of slow Na channels

    • E. 

      Opens K+ channels

    • F. 

      Weak CAI

    • G. 

      Block GABA re-uptake in the presynaptic neuron

    • H. 

      Blocks T-type Ca channels

  • 11. 
    What is the MOA of valproic acid? 
    • A. 

      Enhances slow Na channel inactivation

    • B. 

      Enhances fast Na channel inactivation

    • C. 

      Weak CAI

    • D. 

      Blocks T-type Ca channels

    • E. 

      Increase GABA production

    • F. 

      Block GABA re-uptake in the presynaptic neuron

  • 12. 
    What is the MOA of tiagabine? 
    • A. 

      Blocks T-type Ca channels

    • B. 

      Increase GABA production

    • C. 

      Increase GABA production

    • D. 

      Weak CAI

    • E. 

      Enhances fast Na channels

    • F. 

      Block GABA re-uptake in the presynaptic neuron