Emea Orenstein (Both Papers) And Sandor Test Level 3

14 Questions | Total Attempts: 40

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Emea Orenstein (Both Papers) And Sandor Test Level 3

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Questions and Answers
  • 1. 
    The Human Monocyte Activation by Biologic & Biodegradable Meshes in Vitro paper by Orenstein demonstrated that chronically induced IL-1β can lead to exaggerated activity of __________?
    • A. 

      Interleukin-6

    • B. 

      Interleukin-8

    • C. 

      Interleukin-1β

    • D. 

      Matrix metalloproteinases

    • E. 

      Vascular endothelial growth factor

  • 2. 
    __________ is a key regulatory cytokine necessary for the integration of implanted biomaterials and it acts as the primary inducer of the acute inflammatory response as seen in both Orenstein papers.
    • A. 

      Interleukin-6

    • B. 

      Interleukin-8

    • C. 

      Interleukin-1β

    • D. 

      Vascular endothelial growth factor

  • 3. 
    In the Human Monocyte Activation by Biologic and Biodegradable Meshes in Vitro study by Orenstein, the authors state, “The balance between appropriate wound healing and deleterious sequelae is believed to be controlled by cytokines, growth factors, and other chemical-signaling molecules, with __________ playing pivotal roles.”
    • A. 

      Interleukin-1β

    • B. 

      Vascular endothelial growth factor

    • C. 

      Monocytes/macrophages (M/MØs)

    • D. 

      None of the above

  • 4. 
    In the Human Monocyte Activation by Biologic and Biodegradable Meshes in Vitro study by Orenstein, _________ induced IL-1β production more than _________ times more than AlloDerm®.
    • A. 

      AlloMax™, fifty

    • B. 

      Flex HD®, fifty

    • C. 

      Bio-A, sixty

    • D. 

      AlloMax™, sixty

  • 5. 
    The Human Monocyte Activation by Biologic & Biodegradable Meshes in Vitro paper by Orenstein noted that ____________ activation initiates the inflammatory response and potentially engages the “resorption” mechanism of action.
    • A. 

      Interleukin-1β

    • B. 

      Growth factor

    • C. 

      Macrophage

    • D. 

      Vascular endothelial growth factor

  • 6. 
    The key markers for inflammation in the Orenstein study are:
    • A. 

      IL-1 β

    • B. 

      IL-6

    • C. 

      IL-8

    • D. 

      VEGF

    • E. 

      All of the above

  • 7. 
    In the Activation of human mononuclear cell meshes in vitro study by Orenstein, cytokine expression varied among the four porcine products studied. Which product(s) induced significantly greater quantities of all four cytokines?
    • A. 

      CollaMend™, Permacol™, and Surgisis®

    • B. 

      CollaMend™, Surgisis® and Veritas®

    • C. 

      Permacol™ and Surgisis®

    • D. 

      CollaMend™ and Permacol™

  • 8. 
    In the Activation of human mononuclear cell meshes in vitro study by Orenstein, the greatest cytokine inducer of the four products studied was __________ .
    • A. 

      Surgisis®

    • B. 

      Permacol™

    • C. 

      CollaMend™

    • D. 

      Veritas®

  • 9. 
    In the Activation of human mononuclear cell meshes in vitro study by Orenstein, _________ induced IL-1β production almost _________ times more than the lowest inducer, Strattice™.
    • A. 

      Permacol™, seven

    • B. 

      Surgisis®, seven

    • C. 

      CollaMend™, sixty

    • D. 

      Permacol™, sixty

  • 10. 
    According to Orenstein, et al: exaggerated inflammatory responses may result in excessive __________ , with resultant in scarring and __________ or rapid mesh __________ , leading to graft weakening and hernia repair failure.
    • A. 

      Extrusion, fibrosis, encapsulation

    • B. 

      Inflammation, fibrosis, encapsulation

    • C. 

      Inflammation, fibrosis, degradation

    • D. 

      Fibrosis, encapsulation, degradation

  • 11. 
    Which of the following is a true statement?
    • A. 

      The materials tested in the Sandor paper were: Strattice, Permacol, Collamend & Surgisis

    • B. 

      The materials tested in the Sandor paper were: Permacol, Collamend & Surgisis

    • C. 

      The materials tested in the Sandor paper were: Strattice, Permacol, Collamend & SurgiMend

    • D. 

      The materials tested in the Sandor paper were: Permacol, Collamend & SurgiMend

  • 12. 
    In the Sandor paper, at 6 months, __________ appeared fully infiltrated with a mixed inflammatory response; delamination of the graft was also noted.
    • A. 

      SurgiMend

    • B. 

      Permacol

    • C. 

      CollaMend

    • D. 

      Surgisis

  • 13. 
    Which of the following is a true statement with regard to the Sandor paper?
    • A. 

      Surgisis elicites an extensive immune response by 1-month implantation that may have led to mesh resorption by 6-months

    • B. 

      Immune cells rapidly encapsulated Permacol and Collamend grafts, consistent with foreign body response

    • C. 

      A & B

    • D. 

      None of the Above

  • 14. 
    Sandor et al stated, “poor outcomes for the xenogeneic meshes (Permacol & CollaMend) in this study are believed to be due to _____________________ that damage the biochemical matrix components and may prevent a fully biologic repair”.
    • A. 

      IgG humoral response

    • B. 

      High levels of T & B cells

    • C. 

      Processing techniques

    • D. 

      The source & species from which the product is derived

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