Critical Role Of Neuronal Migration In Neo-cortical Development

20 Questions

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Critical Thinking Quizzes & Trivia

The neocortex is the part of the brain that is involved in higher brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning, and language. These functions are made possible by the ability of neurons to travel to their final position. Take up the quiz below and test your understanding of the critical role of neuronal migration in neocortical development.


Questions and Answers
  • 1. 
    What are the two main extracellular regulatory molecules responsible for radial migration?
    • A. 

      GABA and Lis1

    • B. 

      GABA and Reelin Protein

    • C. 

      Lis1 and Reelin Protein

    • D. 

      DCX and Lis1

  • 2. 
    In tangential migration, what is the substrate used by migrating olfactory interneuron precursors?
    • A. 

      Glial Fibres

    • B. 

      α5 and γ1 Lamins

    • C. 

      α1 and β1 Integrins

    • D. 

      γ5 and β1 Integrins

  • 3. 
    What is the main gene responsible for the brain formation disorder Lissencephaly?
    • A. 

      Tag1

    • B. 

      Lis1

    • C. 

      Rab3

    • D. 

      NELF

  • 4. 
    In tangential migration, GnRH neurons migrate from the ______   ______ .
  • 5. 
    In tangential migration, GnRH neurons migrate from the olfactory placode to the ________ or POA.
  • 6. 
    In tangential migration, GnRH neurons migrate from the olfactory placode to the hypothalamus or POA, using _______ as their substrate.
  • 7. 
    In tangential migration, ________ helps neurons to adhere to the axons during migration.
  • 8. 
    In somal translocation of early corticogenesis, neurons migrate from the ventricular zone of the neural tube to the ____  ______.
  • 9. 
    In glial-guided locomotion of late corticogenesis, neurons migrate radially to form the marginal zone and the subplate, adding to the brain's _________.
  • 10. 
    In radial migration, glial-guided locomotion exhibits a unique pattern of movement that is not seen in any other kind of cell migration, known as a saltatory pattern of locomotion. HINT: a saltatory pattern of locomotion is where something moves foward in sudden bursts, between longer stationary periods.
    • A. 

      True

    • B. 

      False

  • 11. 
    In radial migration, the two main intracellular regulatory molecules are:
    • A. 

      HGF Gli3

    • B. 

      Reelin and Slit1

    • C. 

      PAFAH 1b1 and Lis1

    • D. 

      Lis1 and DCX

  • 12. 
    Which mode of migration is the slowest?
    • A. 

      Tangential

    • B. 

      Somal Translocation

    • C. 

      Multipolar

    • D. 

      Radial

  • 13. 
    Rap1 GTPase stimulates the Reelin Protein to regulate the Neural Cadherins on the cell's surface.
    • A. 

      True

    • B. 

      False

  • 14. 
    In which zone does the golgi apparatus and centrosomes reorient towards the cortical plate, in multipolar migration?
    • A. 

      Ventricular Zone

    • B. 

      Cortical Plate

    • C. 

      Intermediate Zone

    • D. 

      Pial Surface

  • 15. 
    Which of the following is not a symptom of a neuronal migratory disorder?
    • A. 

      Dysarthria

    • B. 

      Epilepsy

    • C. 

      Hypotonia

    • D. 

      Angina

  • 16. 
    The neural migratory disease Polymicrogyria is a result of disrupted tangential migration.
    • A. 

      True

    • B. 

      False

  • 17. 
    Which of the following conditions is not the result of disrupted neuronal migration?
    • A. 

      Bipolar Disorder

    • B. 

      Schizophrenia

    • C. 

      Alzheimer's Disease

    • D. 

      Multiple Sclerosis

  • 18. 
    Please indicate which of the following statements, about GABAergic interneurons in tangential migration, are FALSE:
    • A. 

      A. GABAergic interneurons are the only class of neurons which migrate from the subpallium to the pallium.

    • B. 

      B.HGF and its receptor DDD increase cell migration away from the MGE.

    • C. 

      C. Individually migrating neurons travel through the subplate or MZ directly to the CP.

    • D. 

      D. Sema3A and Sema3F are chemorepulsive factors present in the striatum.

    • E. 

      E. Research suggests that axons are a possible substrate for GABAergic interneurons.

    • F. 

      F. The chemoattractive factors present in the POA are Emx1, Emx2 and NRG-Ig