Carbohydrate Blood Groups
- 1.Which of the following is a carbohydrate blood group antigen?
- A.
D
- B.
Leb
- C.
Jka
- D.
Lua
- E.
S
- 2.A patient's red cells react with anti-A and the serum reacts with group B cells. The ABO blood group is:
- A.
A
- B.
B
- C.
O
- D.
Oh
- E.
AB
- 3.The enzyme responsible for conferring H activity on the red cell membrane is:
- A.
D-galactosyltransferase
- B.
UDP-glucuronosyltransferase (UGT)
- C.
L-fucosyltransferase
- D.
Glycosyltransferase
- E.
N-acetyl-galactosaminytransferase
- 4.The terminal sugar molecule that defines blood group A is:
- A.
N-acetyl-D-neuraminic acid
- B.
L-fucose
- C.
N-acetyl-D-galactosamine
- D.
D-galactose
- E.
N-acetyl-D-glucosamine
- 5.A bleeding patient is in need of Group O blood. From which US ethnic group would one find the most group O donors?
- A.
European American
- B.
African American
- C.
Asian
- D.
Native American
- E.
Melanesian
- 6.In the ABO blood group the mating of which two phenotypes can produce offspring with each of the common 4 blood types? (A, B, AB, O)
- A.
AB and O
- B.
AB and A
- C.
AB and AB
- D.
A and B
- E.
AB and B
- 7.Which of the following statements is true?
- A.
The ABO and Rh gene loci are on chromosome 9
- B.
Anti-A and anti-B made by Group B and A people are predominantly IgM
- C.
A mixed field reaction is typically observed between anti-A and A2 cells
- D.
A1 and A2 subgroups are distinguished serologically with the Ulex europeaus lectin
- E.
Serum of Bombay phenotype people (Oh) will agglutinate group O red cells but will not agglutinate group A or group B red cells
- 8.A blood donor has the genotype hh, AB. What is the apparent red cell phenotype?
- A.
A
- B.
B
- C.
O
- D.
AB
- E.
Cannot detemine
- 9.Bombay phenotype (Oh) individuals:
- A.
Have red cells that do not agglutinate with either anti-A or anti-B but do agglutinate with the Ulex europeaus lectin
- B.
Have naturally occurring anti-A, -B, and -H
- C.
Can be transfused safely with blood from donors of any blood group (A, B, AB, O)
- D.
Have naturally occuring anti-A and anti-B but they are not active at 37C
- E.
Inherit SeSe and the Se locus
- 10.Which one of the following antibodies strongly agglutinates O cells and A2 cells, but either does not agglutinate or only weakly agglutinates A1 and A1B cells?
- A.
Anti-Lea
- B.
Anti-A1
- C.
Anti-A
- D.
Anti-H
- E.
Anti-B
- 11.Which of the following red cell types would be best for demonstrating the presence of anti-I in a patient's serum?
- A.
Adult cells
- B.
Oh Bombay cells
- C.
Cord cells
- D.
Le(a+b+) cells
- E.
I adult cells
- 12.Which of the following statements is true regarding an acquired B antigen?
- A.
It can be acquired through multiple transfusions
- B.
It is not detected by monoclonal anti-B
- C.
It occurs more frequently in lupus
- D.
It has been associated with gram positive bacteria
- E.
It is seen more often in patients with colorectal carcinoma
- 13.50 year old man presents with abdominal mass via CT scan. History is of a B+. Type and screen is ordered and the results are below:Anti-A: 0 Anti-B: 0 Anti-A,B: 0 A1Cell: 4+ BCell: 0His most likely diagnosis is:
- A.
Hepatocellular carcinoma
- B.
Testicular carcinoma
- C.
Carcinoma of the pancreas
- D.
Melanoma
- E.
Adrenal adenocarcinoma
- 14.Which of the following concerning anti-P1 and the P1 antigen is true?
- A.
Anti-P1 is predominantly IgG
- B.
P1 antigen is expressed well on cord cells, equal to that of adult cells
- C.
Antibody to P1 demonstrate equal reactivity with all red cells expressing P1
- D.
The P1 antigen is a member of the P blood group system
- E.
Antibodies to P1 are clinically significant
- 15.With regard to neutralization, which of the following antibody/neutralization pairs is correct?
- A.
Anti-I and human urine
- B.
Lewis antibodies and breast milk
- C.
Anti-Chido and plasma
- D.
Anti-Sda and hydatid cyst fluid
- E.
Anti-P1 and guinea pig urine
- 16.Which of the following antibodies is commonly associated with in-vitro hemolysis?
- A.
Anti-C
- B.
Anti-D
- C.
Anti-Fya
- D.
Anti-K
- E.
Anti-Lea
- 17.Which of the following can form both Lea and Leb antibodies?
- A.
Le(a+b-)
- B.
Le(a-b+)
- C.
Le(a-b-)
- D.
Le(a+b+)
- 18.Which of the following phenotypes or haplotypes occurs more frequently in African Americans than in European Americans?
- A.
A
- B.
I negative adult
- C.
Le(a-b-)
- D.
P
- E.
P2
- 19.Which Lewis phenotype can Bombay (Oh) individuals NOT have?
- A.
Le(a-b-)
- B.
Le(a+b-)
- C.
Le(a-b+)
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