Block 9 Pharm Drug Distribution W Exp

15 Questions | Total Attempts: 813

SettingsSettingsSettings
Please wait...
Block 9 Pharm Drug Distribution W Exp

.


Questions and Answers
  • 1. 
    Which of the following statements best explains why several drugs cannot enter easily the central nervous system?
    • A. 

      Epithelial cells of choroid plexus have no active transport systems

    • B. 

      The protein content of cerebrospinal is much lower than that of plasma

    • C. 

      The pH of cerebrospinal fluid is lower than that of plasma

    • D. 

      Endothelial cells of brain capillaries and choroid plexus have tight junctions

    • E. 

      There are no lymphatic vessels in the brain

  • 2. 
    The placental crossing of different drugs was studied in laboratory animals. The following data were obtained . Which of the following drugs most likely crossed the placenta at the fastest rate?
    • A. 

      Drug A

    • B. 

      Drug B

    • C. 

      Drug C

    • D. 

      Drug D

    • E. 

      Drug E

  • 3. 
    Which of the following statements correctly defines the volume of distribution of a drug?
    • A. 

      The volume of plasma from which the drug is removed per unit time

    • B. 

      The volume of plasma that contain all the administered dose of that drug

    • C. 

      The volume required to contain all the drug in the body at the same concentration as in plasma

    • D. 

      The volume of a body organ that contains all the administered dose of that drug

    • E. 

      The volume required to contain all the drug distributed into the body per unit time

  • 4. 
    A 31-year-old woman (weight 63 Kg) diagnosed with serious endogenous depression started a treatment with imipramine IM. Imipramine has an IM bioavailability of about 1 and a Vd of about 18 L/Kg. Effective plasma concentrations for antidepressant effect are about 0.2 mg/L. The initial IM dose for this patient was most likely in which of the following ranges?
    • A. 

      10-20 mg

    • B. 

      30-50 mg

    • C. 

      100-190 mg

    • D. 

      200-290 mg

    • E. 

      300-400 mg

  • 5. 
    A 58-year-old obese man has been diagnosed with vasospastic angina and a treatment with nifedipine is planned. Nifedipine has a Vd of about 55 liters in a 70 Kg person, but in this obese patient the Vd turned out to be 110 liters. The standard initial therapeutic dose of nifedipine is 30 mg daily. Which of the following should be the initial therapeutic dose for this patient (in mg), to achieve the same plasma concentration given by the standard therapeutic dose?
    • A. 

      20

    • B. 

      40

    • C. 

      60

    • D. 

      90

    • E. 

      120

  • 6. 
    A 10 mg dose of a new drug that follows a first order, one compartment model kinetics, was given IV to voluntary subjects in a phase I clinical trial. The volume of distribution of the drug turned out to be 80 liters. Which of the following would have been (in liters) the volume of distribution of the drug, if the administered dose were 20 mg?
    • A. 

      40

    • B. 

      80

    • C. 

      240

    • D. 

      160

    • E. 

      120

  • 7. 
    A 34-year-old patient is about to receive a morphine injection because of a sharp abdominal pain apparently due to a renal colic. Morphine is a basic drug that crosses the cell membrane by lipid diffusion and has a Vd of about 230 liters (for a 70 kg person). The drug will distribute mainly in which of the following body fluids?
    • A. 

      Cerebrospinal fluid

    • B. 

      Plasma

    • C. 

      Extracellular fluids

    • D. 

      Cell cytosol

    • E. 

      Total body water

  • 8. 
    A 54-year-old alcoholic man was brought to the emergency room in a state of acute ethanol intoxication. Ethanol is a water soluble, non ionizable drug with a MW of about 46. The drug was most likely distributed in which of the following body sites of the patient?
    • A. 

      Fat tissue

    • B. 

      Plasma

    • C. 

      Extracellular fluids

    • D. 

      Cell cytosol

    • E. 

      Total body water

  • 9. 
    The pharmacokinetics of a new drug was studied in voluntary subjects. It was found that the drug followed a first order, one compartment model kinetics and had a Vd of 100 L. After the oral administration of a 200 mg dose the plasma concentration at zero time turned out to be 1 mg/L. Which of the following was most likely the oral bioavailability of the drug?
    • A. 

      0.1

    • B. 

      0.5

    • C. 

      0.8

    • D. 

      1.0

    • E. 

      2.3

    • F. 

      1.6

  • 10. 
    A 54-year-old woman, recently diagnosed with atrial fibrillation, started a treatment with propranolol, 80 mg tablet daily. Propranolol has a MW of about 259 and volume of distribution (Vd) of about 270 liters. Which of the following statements best explains why the drug has this large Vd?
    • A. 

      The drug is highly lipophilic

    • B. 

      The drug distributes in the total body water

    • C. 

      The administered dose of the drug is very high

    • D. 

      The drugs has a low oral bioavailability

    • E. 

      The drug has a very high total clearance

  • 11. 
    A 45-year-old woman suffering from rheumatoid arthritis started a treatment which included infliximab, a monoclonal antibody against TNF-alpha. The drug has volume of distribution (Vd) of about 3 liters. Which of the following was most likely the main site of distribution of this drugs?
    • A. 

      Fat tissue

    • B. 

      Plasma

    • C. 

      Extracellular fluids

    • D. 

      Cell cytosol

    • E. 

      Total body water

  • 12. 
    The pharmacokinetics of a new drug that followed first order, one compartment model kinetics, was studied in healthy subjects. It was found that the oral bioavailability of the drug was 0.5. When a 200 mg dose was given orally, the estimated time-plasma concentration curve was the one depicted below. Which if the following was most likely the volume of distribution of that drug, in liters?
    • A. 

      20

    • B. 

      35

    • C. 

      8

    • D. 

      10

    • E. 

      5

    • F. 

      16

  • 13. 
    Which of the following is the approximate range of variability of the volume of distribution of different drugs (in liters for a 70 kg person)?
    • A. 

      3 - >1000

    • B. 

      10-100

    • C. 

      5 - 100

    • D. 

      15- 500

    • E. 

      1 - >1000

    • F. 

      3 - 300

  • 14. 
    A 43-year-old woman, recently diagnosed with staphylococcal endocarditis, started a treatment which included vancomycin IM. The drug is a highly hydrophilic antibiotic with a molecular weight of about 1500 D. Which of the following was most likely the main site of distribution of this drugs?
    • A. 

      Total body water

    • B. 

      Extracellular fluids

    • C. 

      Cell cytosol

    • D. 

      Plasma

    • E. 

      Fat tissue

  • 15. 
    Placental permeability to drugs is variable during pregnancy. The highest permeability occurs during which of the following periods?
    • A. 

      First week

    • B. 

      Second week

    • C. 

      Second month

    • D. 

      Second trimester

    • E. 

      Third trimester