Block 9 Pharm Drug Absorbtion W Exp

20 Questions | Total Attempts: 649

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Block 9 Pharm Drug Absorbtion W Exp

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Questions and Answers
  • 1. 
    Which of the following mechanisms for transmembrane transport of drugs exhibits selectivity, competition, saturability and does not require metabolic energy ?
    • A. 

      Aqueous diffusion

    • B. 

      Lipid diffusion

    • C. 

      Facilitated diffusion

    • D. 

      Active transport

    • E. 

      Endocytosis

  • 2. 
    Which of the following mechanisms for transmembrane transport of drugs is directly proportional to the concentration gradient of the drug and allows transfer of small molecules (MW < 100) only?
    • A. 

      Aqueous diffusion

    • B. 

      Lipid diffusion

    • C. 

      Facilitated diffusion

    • D. 

      Active transport

    • E. 

      Endocytosis

    • F. 

      Bulk flow transfer

  • 3. 
    A 34-year-old man recently diagnosed with grand mal epilepsy started a treatment with valproic acid, an antiseizure drug with a pKa of 5. What percentage of the drug was most likely lipid soluble in the patient’s duodenal lumen (assuming pH = 7 in the lumen)?
    • A. 

      1%

    • B. 

      24%

    • C. 

      50%

    • D. 

      76%

    • E. 

      99%

  • 4. 
    Which of the following drugs given by oral route will be more ionized in the duodenal lumen (assuming pH = 6.9 in the lumen)?
    • A. 

      Cytarabine (base, pKa = 4.5)

    • B. 

      Prazosin (base, pKa = 6.5)

    • C. 

      Sulfadiazine (acid, pKa = 6.5)

    • D. 

      Methotrexate (acid, pKa= 4.3)

    • E. 

      Metronidazole (base, pKa = 2.5)

  • 5. 
    A weak base that permeates the cell membrane by lipid diffusion can be concentrated in the urine when the urine is more acidic than the blood. Which of the following processes best explains this concentration?
    • A. 

      Receptor mediated endocytosis

    • B. 

      Carrier mediated transport

    • C. 

      Ion trapping mechanism

    • D. 

      ATP dependent transport

    • E. 

      Drug metabolism in the urine

  • 6. 
    Which of the following conditions can delay the absorption of orally administered drugs in most cases?
    • A. 

      A moderate increase in intestinal peristalsis

    • B. 

      The presence of strong pain

    • C. 

      The administration of the drug in aqueous solution

    • D. 

      Large volume of distribution of the drug

    • E. 

      Very low clearance of the drug

  • 7. 
    Which of the following methods of drug administration generally results in the fastest onset of drug effect?
    • A. 

      Subcutaneous injection

    • B. 

      Oral administration

    • C. 

      Transdermal administration

    • D. 

      Rectal administration

    • E. 

      Intramuscular injection

  • 8. 
    Which of the following methods of drug administration is used mainly to localize the effect of a drug at a specific site, so reducing its systemic distribution?
    • A. 

      Intramuscular

    • B. 

      Intraarticular

    • C. 

      Subcutaneous

    • D. 

      Sublingual

    • E. 

      Transdermal

  • 9. 
    Which of the following is a reason for a very low (or even absent) oral bioavailability of a drug?
    • A. 

      The drug is given in aqueous solution

    • B. 

      The first-pass effect of the drug is large

    • C. 

      The drug is half-ionized in the intestinal lumen

    • D. 

      The drug is rapidly excreted by the kidney

    • E. 

      The drug rapidly leaves the vascular compartment

  • 10. 
    Morphine is a drug with a large first pass effect. Which of the following routes of administration of the same dose would result in the lowest area-under-curve (AUC)?
    • A. 

      Rectal

    • B. 

      Intramuscular

    • C. 

      Oral

    • D. 

      Sublingual

    • E. 

      Subcutaneous

  • 11. 
    The pharmacokinetics of five new drugs ( A, B, C, D, E) was studied in healthy volunteers. The same dose of each drugs was administered IV and orally to the same subject on two separate occasions. The results were the following: Which of the following drugs will have the highest oral bioavailability?
    • A. 

      Drug A

    • B. 

      Drug B

    • C. 

      Drug C

    • D. 

      Drug D

    • E. 

      Drug E

  • 12. 
    Which of the following pharmacokinetic parameters can predict the total amount of drug inside the body after the administration of a given dose?
    • A. 

      Cmax

    • B. 

      CL

    • C. 

      AUC

    • D. 

      Vd

    • E. 

      Tmax

    • F. 

      T½

  • 13. 
    A 70-year-old woman is brought to the Emergency Room by his son, who referred that the mother was found lethargic, disoriented and combative few hours before admission. Additional history revealed that she had ingested a large number of aspirin tablets in a suicide attempt. An appropriate therapy was instituted, which included the administration of sodium bicarbonate in order to increase the elimination of salicylate. Which of the following statements best explains the reason of this increased elimination?
    • A. 

      Increased tubular active transport of salicylate

    • B. 

      Decreased renal biotransformation of salicylate

    • C. 

      Decreased bioavailability of salicylate

    • D. 

      Urinary ion-trapping of salicylate

    • E. 

      Increased glomerular filtration of salicylate

  • 14. 
    A 45-year-old diabetic man has been receiving two SC administrations of insulin daily. Which of the following permeation processes best explains the absorption of insulin from the site of injection?
    • A. 

      Bulk flow transfer

    • B. 

      Lipid diffusion

    • C. 

      Facilitated diffusion

    • D. 

      Endocytosis

    • E. 

      Active transport

  • 15. 
    A 23-year-old woman suffering from asthma has been prescribed albuterol by inhalatory route. Albuterol is a bronchodilating drug with a molecular weight of 239. Which of the following permeation processes most likely accounts for the transfer of the drug through the bronchial mucosa?
    • A. 

      Aqueous diffusion

    • B. 

      Lipid diffusion

    • C. 

      Facilitated diffusion

    • D. 

      Endocytosis

    • E. 

      Active transport

  • 16. 
    A 65-year old man suffering from hypertension has being taking hydrochlorothiazide orally, one tablet daily. Hydrochlorothiazide is an acidic drug with a pKa of about 9. Which of the following parts of digestive tract most likely represents the main site of absorption of the drug?
    • A. 

      Oral mucosa

    • B. 

      Stomach

    • C. 

      Small intestine

    • D. 

      Colon

    • E. 

      Rectum

  • 17. 
    A 65-year-old man suffering from Parkinson disease has been taking two tablets of levodopa / carbidopa daily. Which of the following permeation processes most likely accounts for the intestinal absorption of levodopa and carbidopa?
    • A. 

      Aqueous diffusion

    • B. 

      Lipid diffusion

    • C. 

      Facilitated diffusion

    • D. 

      Endocytosis

    • E. 

      Active transport

  • 18. 
    Four different oral dosage forms of the same drug were administered to an healthy volunteer during a phase I clinical trial. The concentration vs. time curves are plotted below. Which of the following dosage forms will give the highest drug concentration in the portal vein?
    • A. 

      Drug A

    • B. 

      Drug B

    • C. 

      Drug C

    • D. 

      Drug D

  • 19. 
    A 82-year-old man was recently admitted to a nursing facility. Diseases listed on admission in his medical record were: anxious depression, atrial fibrillation, COPD and renal insufficiency. Medications taken by the patient included nortriptyline, diazepam metoprolol, theophylline and furosemide. Which of the following administered drugs was most likely more concentrated inside the patient’s gastric cells?
    • A. 

      Nortriptyline (base, pKa 9.7)

    • B. 

      Diazepam (base, pKa of 3.0)

    • C. 

      Metoprolol (base, pKa 9.8)

    • D. 

      Theophylline (acid, pKa of 8.8)

    • E. 

      Furosemide (acid, pKa 3.9)

  • 20. 
    Which of the following mechanisms for transmembrane transport of drugs is a passive and non saturable process that allows diffusion of a constant fraction of the drug into the cell per unit time?
    • A. 

      Active transport

    • B. 

      Lipid diffusion

    • C. 

      Endocytosis

    • D. 

      Facilitated diffusion

    • E. 

      Bulk flow transfer