Increased expression of sulfatase
Defect in testosterone receptor
Over-expression of 5 alpha-reductase
Under-expression of aromatase
Involution of the fallopian tubes
GnRH secreting tumor in the hypothalamus
Destruction of primordial follicles
Loss of normal pituitary function.
Hypersecretion of adrenal cortical hormones
Replacement of the LH surge by an FSH surge
Abolition of the LH surge
Enhanced positive feedback of the hypothalamic-pituitary-gonadal axis
Increased conversion of testosterone to estradiol.
Surgical sectioning of sympathetic nerves to the penis; increased production of nitric oxide by endothelial cells.
Surgical damage to the parasympathetic nerves to the penis; increased production of nitric oxide by endothelial cells.
Damage to endothelial cells of the penis; blockade of nitric oxide synthase.
Surgical damage to parasympathetic nerves to the penis; reduced breakdown of cGMP in vascular smooth muscle
Suppression of luteinizing hormone (LH) and follicle stimulating hormone (FSH).
Reduced synthesis of estradiol by extragonadal tissue.
Enhanced synthesis of androstenedione by extragonadal tissue
Increased frequency and amplitude for release of gonadotropin releasing hormone (GnRH).
Increased release of growth hormone releasing hormone (GHRH) by arcuate neurons of the hypothalamus
Over-expression of luteinizing hormone (LH) and follicle stimulating hormone (FSH).
Under-expression of gonadotropin releasing hormone (GnRH) by the paraventricular nucleus of the hypothalamus
Over-expression of oxytocin by supraoptic neurons (SON) of the hypothalamus
Over-expression of aromatase by granulosa cells of the ovary
Over-expression of cholesterol side chain cleaving enzyme (also known as desmolase) by mitochondria of theca and granulosa cells of the ovary.
Overproduction of oxytocin by the supraoptic nucleus (SON) of the hypothalamus
Overproduction of prolactin by the anterior pituitary gland.
Underproduction of prolactin by the anterior pituitary gland.
Overproduction of progesterone by the placenta
Absence of oxytocin release from the supraoptic nucleus (SON) of the hypothalamus.