Pharm Antimicrobial Systemic Infxn

21 Questions | Total Attempts: 73

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Antimicrobial Quizzes & Trivia

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Questions and Answers
  • 1. 
    A 22-year-old woman with a long history of poly-drug abuse presented with a malodorous, granulating ulcer in her vulva. The woman admitted she had different partners while on vacation. A smear from the lesion revealed the presence of Donovan bodies. Which of the following statements correctly pairs the most likely disease of the patient with the appropriate treatment?
    • A. 

      Granuloma inguinale - Doxycycline

    • B. 

      Syphilis - Penicillin G

    • C. 

      Lymphogranuloma venereum - Cefoxitin

    • D. 

      Chancroid - Metronidazole

    • E. 

      Genital herpes – Vancomycin

  • 2. 
    A 35-year-old woman was admitted to the hospital with one month history of fever, anorexia and weight loss. Physical examination revealed a systolic heart murmur, splinter hemorrhages and petechiae on her soft palate. The patient had a documented allergy to penicillins. The presumptive diagnosis of bacterial endocarditis was confirmed when four sets of blood cultures identified Enterococcus faecalis as the offending pathogen. The bacteria was found to be highly resistant to aminoglycosides and to vancomycin. Which of the following drugs would be most appropriate for this patient?
    • A. 

      Ampicillin

    • B. 

      Cefepime

    • C. 

      Linezolid

    • D. 

      Azithromycin

    • E. 

      Doxycycline

  • 3. 
    A 24-year-old woman, who is in her second semester of pregnancy, complains of burning on urination and bladder pain. Her medical history is significant for a recurrent urinary tract infection and for a congenital long QT syndrome discovered during a routine visit three years ago. A clean catch midstream urine sample shows many gram negative rods which were later found to be sensitive to ceftazidime, aztreonam, imipenem, amoxicillin-clavulanate, piperacillin, and moxifloxacin. Which of these antibiotics would be contraindicated for this patient?
    • A. 

      Ceftazidime

    • B. 

      Aztreonam

    • C. 

      Imipenem

    • D. 

      Amoxicillin-clavulanate

    • E. 

      Piperacillin

    • F. 

      Moxifloxacin

  • 4. 
    A 15-year-old girl complained of watery diarrhea and intermittent abdominal pain with cramps. She was recently diagnosed with streptococcal pharyngitis and started a treatment with erythromycin three days ago. Which of the following statements best explains the most likely reason of her current symptoms?
    • A. 

      Erythromycin kills most bacteria of the intestinal flora

    • B. 

      Erythromycin inhibits water reabsorption by colonic mucosa

    • C. 

      Erythromycin activates motilin receptors in the gut

    • D. 

      Streptococcal toxins stimulate intestinal motility

    • E. 

      Diarrhea is the most common symptoms of an allergic reaction to erythromycin

  • 5. 
    A 22-year-old woman presented with fever and very painful sore throat. The woman was otherwise healthy, but medical history was significant for a congenital long QT syndrome discovered six years ago. On physical examination the throat was erythematous with exudative patches. A gram stain of the exudate showed many gram positive bacteria. Which of the following drugs would be contraindicated in this woman?
    • A. 

      Tetracycline

    • B. 

      Amoxicillin

    • C. 

      Cefepime

    • D. 

      Erythromycin

    • E. 

      Trimethoprim-sulfamethoxazole

  • 6. 
    A 15-day-old baby was admitted to pediatric ward with mucopurulent ocular discharge, edema of the eyelids and pseudomembrane formation. A gram stain of the exudate revealed no microorganisms. A Giemsa’s stain showed cytoplasmic inclusions. A topical and systemic treatment was prescribed. Which of the following drugs was most likely administered?
    • A. 

      Tetracycline

    • B. 

      Erythromycin

    • C. 

      Ciprofloxacin

    • D. 

      Trimethoprim-sulfamethoxazole

    • E. 

      Ampicillin

    • F. 

      Tobramycin

  • 7. 
    A 62-year-old alcoholic man presented to the emergency room with fever (103 F), chest pain and cough productive of mucoid sputum. Physical examination revealed a man in obvious distress with the following vital signs: blood pressure 140/85 mm Hg , pulse rate 55 bpm, and respiration rate 22/min. Sputum culture showed gram-negative rods able to grow only on a charcoal yeast extract agar. Which of the following antibiotics would be most appropriate for this patient?
    • A. 

      Streptomycin

    • B. 

      Penicillin G

    • C. 

      Azithromycin

    • D. 

      Vancomycin

    • E. 

      Gentamicin

    • F. 

      Metronidazole

  • 8. 
    Which of the following diseases is most likely to occur when chloramphenicol is administered to a neonate without dose adjustment and plasma level monitoring?
    • A. 

      Acute renal failure

    • B. 

      Ototoxicity

    • C. 

      Optic neuritis

    • D. 

      Gray-baby syndrome

    • E. 

      Hyperuricemia

  • 9. 
    A 71-year-old woman resident of a nursing facility was admitted to the hospital because of high fever, shortness of breath and cough productive of purulent sputum. X-ray film of the chest showed several areas of infiltration with possible abscess formation. A blood culture indicated that the infection was due to staphylococci and an antibiotic sensitivity test showed that they were resistant to methicillin and vancomycin. Which of the following antibiotics would be most appropriate for this patient?
    • A. 

      Nafcillin

    • B. 

      Tetracycline

    • C. 

      Amikacin

    • D. 

      Cefoperazone

    • E. 

      Erythromycin

    • F. 

      Linezolid

  • 10. 
    Which of the following statements regarding fluoroquinolones is correct?
    • A. 

      They prevent the relaxation of supercoiled DNA

    • B. 

      Their ultimate effect is mainly bacteriostatic

    • C. 

      Resistance is completely crossed between quinolones and sulfonamides

    • D. 

      They are primarily effective against Gram-positive bacteria

    • E. 

      They are much safer than penicillin group during pregnancy

  • 11. 
    Which of the following antibacterial drugs is effective against most Gram-negative bacteria, including Pseudomonas aeruginosa, as well as against some mycoplasmas, chlamydiae and mycobacteria?
    • A. 

      Piperacillin

    • B. 

      Ceftazidime

    • C. 

      Ciprofloxacin

    • D. 

      Erythromycin

    • E. 

      Vancomycin

  • 12. 
    Which of the following statements best explains why fluoroquinolones are contraindicated in prepuberal children?
    • A. 

      They are deposited on developing bones and teeth

    • B. 

      They can cause arthropathy by eroding articular cartilage

    • C. 

      They commonly cause anaphylactic shock in prepubertal children

    • D. 

      They have very long half lives in prepuberal children

    • E. 

      They inhibit the production of gonadal hormones in both sexes

  • 13. 
    The mechanism of action of sulfonamides includes a competitive inhibition of which of the following enzymes?
    • A. 

      Purine phosphoribosyl transpherase

    • B. 

      Transpeptidase

    • C. 

      Topoisomerase II

    • D. 

      Dihydropteroate synthetase

    • E. 

      Dihydrofolate reductase

    • F. 

      RNA polymerase

  • 14. 
    Which of the following statements is correct about the pharmacokinetics of sulfonamides?
    • A. 

      Oral bioavailability of systemically used compounds is very poor

    • B. 

      The half-life of all compounds is less than 2 hours

    • C. 

      Concentrations in the CSF are negligible

    • D. 

      Therapeutic concentrations can be achieved in urine

    • E. 

      When given to a pregnant woman concentrations in fetal blood are very low

  • 15. 
    Which of the following bacterial enzyme is inhibited by trimethoprim to inhibit tetrahydrofolate synthesis?
    • A. 

      Dihydropteroate synthetase

    • B. 

      Dihydrofolate reductase

    • C. 

      DNA gyrase

    • D. 

      Topoisomerase IV

    • E. 

      Transpeptidase

  • 16. 
    A 52-year-old man presented with the complaints of feeling tired and passing dark colored urine. Five days ago he was started on an antibiotic therapy for the treatment of a urinary tract infection. Past history was significant for glucose-6-phosphate dehydrogenase deficiency. Urinalysis revealed bilirubin and urobilinogen. Which of the following drugs had most likely caused these findings?
    • A. 

      Piperacillin

    • B. 

      Gentamicin

    • C. 

      Trimethoprim

    • D. 

      Sulfamethoxazole

    • E. 

      Ciprofloxacin

  • 17. 
    A 22-year-old man was admitted to the hospital because of an erythematous, macular eruption on the extremities, followed by the appearance of vesicles and bullae on the lips, oral mucosa, anogenital region and conjunctiva. Few days ago, he started a treatment with trimethoprim-sulfamethoxazole for an acute pharyngitis. Vital signs on admission were: temperature 103 F, pulse 120 bpm, blood pressure 120/78 mm Hg, respirations 30/min. Which of the following best explains the syndrome of this patient?
    • A. 

      Lupoid syndrome

    • B. 

      Disulfiram reaction

    • C. 

      Dermatophytosis

    • D. 

      Bilirubin encephalopathy

    • E. 

      Stevens-Johnson syndrome

    • F. 

      Gray-baby syndrome

    • G. 

      Myelosuppression

  • 18. 
    A 25-year-old woman, late in her third trimester of pregnancy, presented with low grade fever and burning on urination. The history of the patient was significant for a recurrent urinary tract infection. An antibiotic treatment was prescribed. Which of the following drugs would be contraindicated in this patient because of a risk of kernicterus in the newborn?
    • A. 

      Piperacillin

    • B. 

      Sulfamethoxazole

    • C. 

      Cefotaxime

    • D. 

      Imipenem

    • E. 

      Ciprofloxacin

    • F. 

      Gentamicin

  • 19. 
    A 30-year-old, HIV seropositive man presents with nonproductive cough, moderate fever, mild dyspnea, facial seborrheic dermatitis and a CD4 lymphocyte count of 150/mm. A silver-stained preparation from bronchial lavage reveals a large number of cysts containing sporozoites. Which of the following statements correctly pairs the most likely offending pathogen with the appropriate treatment?
    • A. 

      Pneumocystis jiroveci - trimethoprim-sulfamethoxazole

    • B. 

      Pneumocystis jiroveci - aztreonam

    • C. 

      Entamoeba histolytica - paromomycin

    • D. 

      Toxoplasma gondii - ciprofloxacin

    • E. 

      Toxoplasma gondii - gentamicin

  • 20. 
    For the treatment of uncomplicated falciparum malaria one of the drugs is a combination of pyrimethamine and a sulfonamide. Which of the following sufonamides is combined with pyrimethamine for this indication?
    • A. 

      Sulfadoxine

    • B. 

      Sulfadiazine

    • C. 

      Sulfamethoxazole

    • D. 

      Sulfacetamide

    • E. 

      Sulfapyridine

  • 21. 
    A55-year-old woman developed watery diarrhea, nausea and vomiting and abdominal cramps after a dinner with her family at a fast-food restaurant. The next day several other family members developed the same symptoms. The woman medical history is significant for a right hip prosthesis. Stool cultures revealed salmonella species. Which of the following drugs would be an appropriate treatment for this patient?
    • A. 

      Erythromycin

    • B. 

      Dicloxacillin

    • C. 

      Ciprofloxacin

    • D. 

      Ketoconazole

    • E. 

      Vancomycin

    • F. 

      Ribavirin