Pharmacology Quiz On Antiprotozoal Drugs!

20 Questions | Total Attempts: 3128

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Pharmacology Quiz On Antiprotozoal Drugs!

In today’s quiz on pharmacology, we’ll be looking at the drugs that aid in the prevention of protozoan infections – parasitic diseases that are caused by organisms from the Kingdom Protozoa. What can you tell us about antiprotozoal drugs? Take the quiz now and we’ll find out!


Questions and Answers
  • 1. 
    A 34-year-old woman complained of itching and burning around her vagina and a foulsmelling vaginal discharge. A wet mount examination of the discharge showed pear-shaped trophozoites that exhibited jerky motility. Which of the following drugs would be appropriate for this patient?
    • A. 

      Terbinafine

    • B. 

      Nystatin

    • C. 

      Sulfadoxine

    • D. 

      Metronidazole

    • E. 

      Paromomycin

    • F. 

      Fluconazole

  • 2. 
    A 35-year-old woman, back from a tourist trip in the Amazona forest, developed a red papule in her right arm, which enlarged slowly and began to ulcerate but caused no pain. A few days later multiple lesions developed. A smear taken from the skin lesions demonstrated the presence of amastigotes. Which of the following drugs would be appropriate for this patient?
    • A. 

      Metronidazole

    • B. 

      Sodium stibogluconate

    • C. 

      Doxycycline

    • D. 

      Ceftriaxone

    • E. 

      Chloroquine

    • F. 

      Clindamycin

  • 3. 
    A 23-year-old man, coming back from a trip to Peru complained of abdominal discomfort and occasional foul-smelling diarrhea alternating with constipation of a 2-week duration. Stools culture was negative for bacterial pathogens. Which of the following drugs would be an appropriate empiric treatment for the patient at this time?
    • A. 

      Chloroquine

    • B. 

      Ketoconazole

    • C. 

      Metronidazole

    • D. 

      Pyrimethamine

    • E. 

      Quinidine

    • F. 

      Fluconazole

  • 4. 
    A 42-year-old man recently admitted to a mental hospital because of a schizoaffective disorder, complained of diarrhea and stomach cramps. Trophozoites and cysts were observed in his stools specimen. A duodenum string test was also positive for heart-shaped trophozoites with 4 pairs of flagella. Which of the following drugs would be appropriate for this patient?
    • A. 

      Paromomycin

    • B. 

      Metronidazole

    • C. 

      Primaquine

    • D. 

      Ciprofloxacin

    • E. 

      Pyrimethamine

    • F. 

      Fluconazole

  • 5. 
    A 24-year-old woman, who was 22-week pregnant, presented with a 5-day history of loose stools containing bloody mucus. Her past medical history was significant for an optic neuritis one month ago, apparently due to a viral infection. Upon physical examination, her abdomen was soft but nontender. The exam of fresh stools showed E. histolytica trophozoites. A CT scan was negative for gut wall or liver amebiasis. Which of the following drugs would be appropriate for this patient?
    • A. 

      Metronidazole

    • B. 

      Chloroquine

    • C. 

      Clindamycin

    • D. 

      Paromomycin

    • E. 

      Pyrimethamine

    • F. 

      Sulfadoxine

  • 6. 
    A 31-year-old homosexual man presented to the hospital with a 10-day history of abdominal pain and multiple, brown, watery stools. Physical examination revealed a tall man with abdominal distress. Vital signs were: blood pressure 125/75 mm Hg, pulse 78 bpm, temperature 103.5° F. His abdomen was slightly distended with a tender mass palpable in the lower right quadrant, which proved to be an abdominal abscess on ultrasound examination. A serologic test was positive for E . histolytica . Which of the following pairs of drugs would be appropriate for this patient?
    • A. 

      Metronidazole and iodoquinol

    • B. 

      Chloroquine and clindamycin

    • C. 

      Metronidazole and pyrimethamine

    • D. 

      Doxycycline and iodoquinol

    • E. 

      Chloroquine and ciprofloxacin

    • F. 

      Pyrimethamine and ciprofloxacin

  • 7. 
    A 34-year-old black man permanent US is planning to visit his seriously ill father who lives in Uganda. He will be accompanied by his wife and son. Knowing that chloroquine-resistant strains of malaria are present in Uganda, which of the following drugs used alone should be administered to the man, his wife, and son before entering Uganda?
    • A. 

      Primaquine

    • B. 

      Metronidazole

    • C. 

      Pyrimethamine

    • D. 

      Mefloquine

    • E. 

      Chloroquine

    • F. 

      Quinine

  • 8. 
    A 33-year-old man was planning a vacation to sub-Saharan Africa where chloroquine-resistant strains of P. falciparum are present. Which of the following drugs combinations would be appropriate to prevent infection in this man?
    • A. 

      Primaquine-quinine

    • B. 

      Mefloquine-metronidazole

    • C. 

      Pyrimethamine-sulfadoxine

    • D. 

      Doxycycline-iodoquinol

    • E. 

      Chloroquine-paromomycin

  • 9. 
    A 31-year-old man, coming back from a trip to Malaysia, was admitted to the hospital with a two day history of fever, chills and bouts of diarrhea. A Giemsa blood smear demonstrated P. Vivax trophozoites. The patient was placed on chloroquine for 5 days, then he was instructed to take another drug for 14 days. Which of the following drugs was most likely prescribed?
    • A. 

      Primaquine

    • B. 

      Mefloquine

    • C. 

      Quinidine

    • D. 

      Pyrimethamine

    • E. 

      Doxycycline

    • F. 

      Sulfadoxine

  • 10. 
    A 45-year-old black man referred to his physician that few days ago he noticed a persistent yellow color in his eyes . One week before, coming back from a trip to central America, the man had started a treatment which included primaquine. A blood test disclosed the following: RBC count: 3.8 x 106/ mm3 (normal: 4-5.5) Hb: 9 g/dL (normal: > 12) Reticulocytes: 3.7% of red cells (normal 0.5-1.5%) WBC count 12000/mm3 (normal: 3200-9800) The physician told the patient that he probably had a genetically induced enzyme defect. Which of the following enzymes was most likely abnormal?
    • A. 

      Thymidylate synthase

    • B. 

      Uroporphyrinogen decarboxylase

    • C. 

      Pyruvate kinase

    • D. 

      Dihydrofolate reductase

    • E. 

      Glucose-6-phosphate-dehydrogenase

  • 11. 
    A 55-year-old man, who was about to leave for a vacation trip to central Africa, started a treatment with mefloquine. Which of the following plasmodia cells can be effectively killed by the drug?
    • A. 

      P. Vivax hypnozoites

    • B. 

      P. Falciparum gametocytes

    • C. 

      P. Vivax tissue schizonts

    • D. 

      P. Falciparum hypnozoites

    • E. 

      P. Malarie blood schizonts

    • F. 

      P. Malarie tissue schizonts

  • 12. 
    A 35-year-old woman was planning a trip to malaria endemic regions of central America. She was advised by her physician to take a tablet of pyrimethamine-sulfadoxine (fansidar) in  case of fever and then to obtain as soon as possible medical attention. The antimalarial efficacy of pyrimethamine is most likely mediated by the inhibition of which of the following protozoal enzymes?
    • A. 

      Purine phosphoribosyl transferase

    • B. 

      Ornithine decarboxylase

    • C. 

      Ferredoxin oxidoreductase

    • D. 

      Dihydropteroate synthetase

    • E. 

      Dihydrofolate reductase

  • 13. 
    A 43-year-old man is about to leave for a vacation trip to central America. He is advised by his physician to take mefloquine as a prophylactic measure, since he knew that chloroquine resistance was widespread and increasing. Which of the following phrase best explains the likely mechanism of plasmodial resistance to chloroquine?
    • A. 

      Increased inactivation of the drug

    • B. 

      Increased activity of DNA repair mechanism

    • C. 

      Increased drug transport outside plasmodia cells

    • D. 

      Decreased chloroquine binding sites on plasmodia cells

    • E. 

      Decreased of conversion of free heme into hemozoin

  • 14. 
    A 45-year-old reporter who was about to leave for Honduras, started a prophylactics antimalarial treatment with chloroquine. Which of the following molecular actions most likely mediate the therapeutic effect of this drug?
    • A. 

      Inhibition of dihydropteroate synthase

    • B. 

      Blockade of translocation of peptidyl-tRNA

    • C. 

      Incorrect amino acid incorporation into the polypeptide chain

    • D. 

      Inhibition of DNA-dependent RNA polymerase

    • E. 

      Prevention of polymerization of free heme into hemozoin

  • 15. 
    DIRECTIONS 15-19 Match each antiprotozoal drug with the appropriate description (each lettered option can be selected once, more than once or not at all): This antimalarial drug is an effective blood schizonticide, and is also used in the treatment of rheumatoid arthritis.
    • A. 

      Chloroquine

    • B. 

      Clindamycin

    • C. 

      Doxycycline

    • D. 

      Iodoquinol

    • E. 

      Mefloquine

    • F. 

      Metronidazole

    • G. 

      Paromomycin

    • H. 

      Primaquine

    • I. 

      Pyrimethamine

    • J. 

      Quinine

    • K. 

      Sodium stibogluconate

    • L. 

      Sulfadoxine

  • 16. 
    DIRECTIONS 15-19 Match each antiprotozoal drug with the appropriate description (each lettered option can be selected once, more than once or not at all): This drug can kill most anaerobic bacteria and anaerobic protozoa.
    • A. 

      Chloroquine

    • B. 

      Clindamycin

    • C. 

      Doxycycline

    • D. 

      Iodoquinol

    • E. 

      Mefloquine

    • F. 

      Metronidazole

    • G. 

      Paromomycin

    • H. 

      Primaquine

    • I. 

      Pyrimethamine

    • J. 

      Quinine

    • K. 

      Sodium stibogluconate

    • L. 

      Sulfadoxine

  • 17. 
    DIRECTIONS 15-19 Match each antiprotozoal drug with the appropriate description (each lettered option can be selected once, more than once or not at all): This drug has a very long half life (about 20 days).
    • A. 

      Chloroquine

    • B. 

      Clindamycin

    • C. 

      Doxycycline

    • D. 

      Iodoquinol

    • E. 

      Mefloquine

    • F. 

      Metronidazole

    • G. 

      Paromomycin

    • H. 

      Primaquine

    • I. 

      Pyrimethamine

    • J. 

      Quinine

    • K. 

      Sodium stibogluconate

    • L. 

      Sulfadoxine

  • 18. 
    DIRECTIONS 15-19 Match each antiprotozoal drug with the appropriate description  (each lettered option can be selected once, more than once or not at all): This antimalarial drug can kill the late tissue schizonts of P vivax and P. Ovale.  
    • A. 

      Chloroquine

    • B. 

      Clindamycin

    • C. 

      Doxycycline

    • D. 

      Iodoquinol

    • E. 

      Mefloquine

    • F. 

      Metronidazole

    • G. 

      Paromomycin

    • H. 

      Primaquine

    • I. 

      Pyrimethamine

    • J. 

      Quinine

    • K. 

      Sodium stibogluconate

    • L. 

      Sulfadoxine

  • 19. 
    DIRECTIONS 15-19 Match each antiprotozoal drug with the appropriate description  (each lettered option can be selected once, more than once or not at all): This drug can rarely cause the ‘blackwater fever’ in sensitized persons under antimalarial treatment.
    • A. 

      Chloroquine

    • B. 

      Clindamycin

    • C. 

      Doxycycline

    • D. 

      Iodoquinol

    • E. 

      Mefloquine

    • F. 

      Metronidazole

    • G. 

      Paromomycin

    • H. 

      Primaquine

    • I. 

      Pyrimethamine

    • J. 

      Quinine

    • K. 

      Sodium stibogluconate

    • L. 

      Sulfadoxine

  • 20. 
    A 41-year-old woman, coming back from a trip to Kenia, was admitted to the hospital because of malaise, myalgia, abdominal pain, and fever (104 F). The recent history of the patient was significant for two paroxysmal attacks of chills, fever, and vomiting. The first attack lasted a day and was followed by a second 36 hours later. Physical examination revealed an acutely hill patient complaining of severe abdominal pain. Palpation showed a tender, soft, and enlarged spleen. Examination of a stained blood specimen revealed ringlike and crescent-like forms within the RBCs. Which of the following pairs of drugs would be appropriate for this patient?
    • A. 

      Quinidine and doxycycline

    • B. 

      Primaquine and clindamycin

    • C. 

      Pyrimethamine and metronidazole

    • D. 

      Chloroquine and paromomycin

    • E. 

      Mefloquine and ciprofloxacin

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