1.
1. Prostaglandins (chemical mediators) are secreted during the inflammatory process. The effects of prostaglandins include:
A. 
Vasoconstriction and pain
B. 
C. 
Pain and coolness of skin
D. 
Decreased capillary permeability and coolness of skin
2.
2. A client is ordered to receive an NSAID for a disorder. The client states that he is aware that NSAIDs are frequently taken to decrease inflammation. The nurse clarifies that these agents may also be taken to:
A. 
B. 
C. 
D. 
Increase platelet aggregation
3.
3. A nurse is teaching a client who has been prescribed NSAIDs for osteoarthritis. The nurse instructs the client that a common side effect of NSAIDs is:
A. 
B. 
Gastrointestinal upset or distress
C. 
D. 
4.
4. A nurse is working on a pediatric unit. One of the client’s parents asks the nurse why aspirin is not used with children. The nurse’s response is based on the fact that aspirin is contraindicated if a child has:
A. 
B. 
C. 
D. 
Inflammation from an injury
5.
5. A client is ordered to receive aspirin after an acute heart attack. The nurse is evaluating use of this medication with other medications. The nurse is aware that aspirin can cause which of the following drug interactions?
A. 
Increased risk of bleeding with anticoagulants
B. 
Decreased risk of hypoglycemia with oral hypoglycemic drugs
C. 
Decreased ulcerogenic effect with glucocorticoids
D. 
Increased risk of infection with amoxicillin
6.
6. A group of clients cared for by the nurse is ordered to take NSAIDs. All of the following instructions are possible. Which of the following client instructions would the nurse question?
A. 
Instruct the client not to take aspirin and other NSAIDs together.
B. 
Instruct the client to take NSAIDs with meals or 8 ounces of fluid.
C. 
Instruct women to take NSAIDs during heavy menstrual flow for pain.
D. 
Instruct the client to avoid alcohol when taking NSAIDs.
7.
7. The population of clients most often responsive to the NSAID groups of medications is those with:
A. 
Rheumatoid arthritis and osteoarthritis
B. 
Postoperative pain and discomfort
C. 
Infections and incisional pain
D. 
Gastrointestinal discomfort and bleeding
8.
8. The nurse is caring for a client with rheumatoid arthritis. The nurse is aware that disease-modifying antirheumatic drugs (DMARDs) may be prescribed when NSAIDs do not control immune-mediated arthritic disease sufficiently. Which of the following is a DMARD?
A. 
B. 
C. 
D. 
9.
9. A client is ordered to receive gold therapy. The client asks how long it will take for him to feel the effects of this medication. The nurse responds that gold medications generally:
A. 
Achieve the desired effect in 1 to 2 months
B. 
Achieve the desired effect in 3 to 6 months
C. 
Alleviate symptoms immediately
D. 
Are effective within days of treatment
10.
10. A client is ordered to receive auranofin (Ridaura) for her advanced arthritic condition. The nurse instructs the client that this medication is administered:
A. 
B. 
C. 
D. 
11.
11. A client is receiving auranofin (Ridaura). Which of the following instructions takes priority?
A. 
“You may lose your hair.”
B. 
“Your skin may become reddened and irritated.”
C. 
“You need to take the medicine with food to avoid stomach upset.”
D. 
“Frequent blood tests must be done.”
12.
12. A client is ordered to receive colchicine (Novocolchine) for an acute gout episode. Colchicine, an antigout drug, acts by inhibiting:
A. 
B. 
Migration of leukocytes to the inflamed site
C. 
D. 
Synthesis of white and red blood cells
13.
13. A client with gout is ordered to receive a medication that acts by increasing uric acid excretion. This drug is:
A. 
B. 
C. 
Aurothioglucose (Solganal)
D. 
14.
14. Client teaching related to colchicine (Novocolchine) includes which of the following?
A. 
Encourage the client to take antigout drugs on an empty stomach.
B. 
Instruct the client to increase fluid intake.
C. 
Instruct the client to adhere to an acid-ash diet.
D. 
Instruct the client that foods rich in purine decrease gout symptoms.
15.
15. A client with rheumatoid arthritis is ordered to receive tumor necrosis factor as treatment for symptoms. The manifestations of most concern to the nurse include:
A. 
Elevated temperature and a sore throat
B. 
Decreased range of motion and crepitation
C. 
Constipation and abdominal pain
D. 
Poor skin turgor and increased urine specific gravity
16.
16. Indomethacin (Indocin) is highly protein-bound and is ordered as a new medication for the client. The client is taking another medication that is moderately protein-bound. Upon administration of both medications, the nurse is most concerned with:
A. 
B. 
Indomethacin levels below the therapeutic level
C. 
An increase in medication side effects
D. 
Toxic levels of the first drug
17.
17. A client is ordered to receive acetaminophen (Tylenol) for mild pain. The client asks how this medication works. The nurse instructs him that Tylenol:
A. 
Decreases levels of dopamine in the body
B. 
Inhibits prostaglandin synthesis
C. 
Regulates the neurotransmitters in the body
D. 
Prohibits the body’s inflammatory response
18.
18. A child is diagnosed with a viral syndrome. The parent contacts the nurse practitioner for a recommendation for over-the-counter medication. Which medication is contraindicated?
A. 
B. 
C. 
D. 
19.
19. A client asks the nurse questions about NSAIDs. The nurse instructs the client that NSAIDs are frequently taken to decrease inflammation; however, these agents may also be taken to:
A. 
B. 
C. 
D. 
Increase platelet aggregation
20.
20. In teaching a client about NSAIDs, the nurse is careful to teach about how to monitor for side effects. The following side effect is of special concern to older adults:
A. 
B. 
C. 
D. 
Gastrointestinal upset or distress
21.
21. A client enters the emergency clinic with the following symptoms: difficulty walking, pain in his toes, and aches in his feet. The nurse would anticipate giving which of the following medications to treat his acute gout episode?
A. 
B. 
C. 
D. 
Colchicine (Novocolchine)
22.
22. A client is ordered to receive celecoxib (Celebrex) for chronic pain caused by osteoarthritis. The nurse should assess the patient with the knowledge that the following pathophysiologic change is associated with the COX-2 inhibitors:
A. 
An increase in pain level
B. 
An increase in bleeding time
C. 
Erosion of the stomach lining
D. 
23.
23. A client is ordered to receive a medication to relieve inflammation. The nurse evaluates that the medication is needed quickly. Which drug form is most rapidly absorbed from the gastrointestinal (GI) tract?
A. 
B. 
C. 
D. 
24.
24. A client is ordered to receive an NSAID for osteoarthritis. The most common side effect may be treated with which of the following nursing interventions?
A. 
Taking the medication with meals
B. 
C. 
D. 
Encouraging deep breathing