Cumulative Vetprep Pharmacology Practice Final

50 Questions

Settings
Please wait...
Pharmacology Quizzes & Trivia

A variety of multiple choice, true-false, and multiple-multiple choice questions


Questions and Answers
  • 1. 
    What is a lotion?
    • A. 

      A liquid or semisolid preparation to be applied on the skin with friction

    • B. 

      A semisolid preparation that can be used for external use

    • C. 

      A drug in a water-oil emulsion which is applied to the skin

    • D. 

      A solution or suspension of soothing substances to be applied on the skin in acute inflammation to relieve pain

  • 2. 
    Which is not a local route of administration?
    • A. 

      Intraspinal

    • B. 

      Intraperitoneal

    • C. 

      Intra-articular

    • D. 

      Intramedullary

  • 3. 
    A disadvantage to subcutaneous administration of a drug is that the presence of of other drugs may affect absorption
    • A. 

      True

    • B. 

      False

  • 4. 
    Select all of the schedules of controlled drugs that must contain the warning: "Caution: Federal law prohibits the transfer of this drug to any person other than the (client and) patient for whom it was prescribed" on the label of the container.
    • A. 

      C-I

    • B. 

      C-II

    • C. 

      C-III

    • D. 

      C-IV

    • E. 

      C-V

  • 5. 
    Calculate the therapeutic index of a drug in which ED1= 1mL, ED50= 5mL, ED99= 10mL, LD1= 15mL, LD50= 20mL, and LD99=  25mL.
    • A. 

      2

    • B. 

      4

    • C. 

      33

    • D. 

      60

  • 6. 
    Calculate the stardard safety margin of a drug in which ED50= 5mL, ED99= 10mL, LD1= 15mL, and LD99=  20mL.
    • A. 

      2

    • B. 

      4

    • C. 

      33

    • D. 

      60

  • 7. 
    A patient is ordered 0.5 milligrams of Digoxin. 250 microgram tablets are available. How many tablets will you give?
    • A. 

      1 tablet

    • B. 

      1.5 tablets

    • C. 

      2 tablets

    • D. 

      4 tablets

  • 8. 
    A patient is ordered 50 milligrams of Amoxicillin trihydrate orally. 125 milligrams in 5 milliliters of syrup is available. How many milliliters will you administer?
    • A. 

      2 mL

    • B. 

      5 mL

    • C. 

      12.5 mL

    • D. 

      15 mL

  • 9. 
     A patient is ordered 22 milligrams of Gentamicin sulphate by intramuscular injection. 0.33 grains in 2 millilitres of liquid for IM Injection is available. How many millilitres will you administer?
    • A. 

      0.3 mL

    • B. 

      2.2 mL

    • C. 

      3.6 mL

    • D. 

      14.5 mL

  • 10. 
    Calculate the drip rate for 100 mL of IV fluids to be given over a half hour via a giving set which delivers 10 drops/ml.
    • A. 

      0.33 gtt/ min

    • B. 

      0.66 gtt/ min

    • C. 

      5 gtt/min

    • D. 

      33 gtt/min

  • 11. 
    One liter of normal saline is charted over 9 hours. The drop factor is 15 gtt/mL. Calculate the number of drops per minute.
    • A. 

      2 gtt/ min

    • B. 

      28 gtt/ min

    • C. 

      36 gtt/ min

    • D. 

      100 gtt/ min

  • 12. 
    A veterinarian hands you a 1.5L bottle of a 20% solution and asks that you mix it with sterile water to make as much 12% solution as possible. How much sterile water will you use ?
    • A. 

      525 mL

    • B. 

      800 mL

    • C. 

      1000 mL

    • D. 

      1250 mL

  • 13. 
    How much 150 proof ethanol is needed to make 25 fl.  oz 70% solution?
    • A. 

      350 mL

    • B. 

      420 mL

    • C. 

      700 mL

    • D. 

      800 mL

  • 14. 
    Trimethoprim-sulfonamide is an example of potentiation
    • A. 

      True

    • B. 

      False

  • 15. 
    Which of the following describes a slighty toxic drug?
    • A. 

      5-15 g/kg

    • B. 

      0.05-0.5 g/kg

    • C. 

      50-500 mg/kg

    • D. 

      500 -5000 mg/kg

  • 16. 
    Chronocity factor is the ratio between acute LD50 and chronic LD50.
    • A. 

      True

    • B. 

      False

  • 17. 
    Select the all the transport mechanisms that require energy
    • A. 

      Exchangers

    • B. 

      Paracellular movement

    • C. 

      Simple diffusion

    • D. 

      Pinocytosis

    • E. 

      Bulk flow

    • F. 

      Carrier-mediated transport via facilitated diffusion

    • G. 

      Primary active transport

    • H. 

      Secondary active transport

    • I. 

      Transmembrane movement

    • J. 

      Symporters

  • 18. 
    Acidic drugs ionize in basic medium and basic drugs ionize in alkaline medium.
    • A. 

      True

    • B. 

      False

  • 19. 
    Select all mediums in which acidic drugs will be non-ionized
    • A. 

      Gastric juices

    • B. 

      Alkaline medium

    • C. 

      Acidic medium

    • D. 

      Pancreatic juices

    • E. 

      Bicarbonate solution

  • 20. 
    The higher the pH of a medium in which a weak acid is in, the lower is N/I.  Likewise, the lower the pH of a medium in which a weak base is in, the greater is N/I.
    • A. 

      True

    • B. 

      False

  • 21. 
    The higher the pka of a weak acid, the greater is N/I and the lower the pka of a weak base the greater is N/I
    • A. 

      True

    • B. 

      False

  • 22. 
    Drugs like d-tubocurarine (a quaternary ammonium compound) are mostly non ionized.
    • A. 

      True

    • B. 

      False

  • 23. 
    The pH of the stomach is 2.5.  The pKa of sodium pentothal is 7.4 and it is acidic.  If a patient is given sodium pentothal orally instead of IV, will it put the patient to sleep?
    • A. 

      Yes, because none of the sodium pentothal is ionized in the stomach. Therefore the patient would absorb 100% of this medication and it would put him to sleep.

    • B. 

      No, because the sodium pentothal is ionized in the stomach. Therefore the patient would not absorb this medication and it would not put him to sleep.

  • 24. 
    A basic drug with a pKa of 8.4 is a known teratogen.  Will this drug cross the placenta and effect the fetus if given IV to a pregnant mare?  
    • A. 

      Yes, 10% of the drug will cross the placenta and effect the fetus.

    • B. 

      Yes, 90% of the drug will cross the placenta and effect the fetus.

    • C. 

      No, the drug is 100% ionized and cannot cross the placenta.

    • D. 

      No, the placenta is an excellent physiological barrier; only nutrients from the mother and waste products from the fetus cross it.

  • 25. 
    If pKa - pH = 0.5, then the solution is 75% ionized/ 25% unionized or 75% unionized/ 25% ionized.
    • A. 

      True

    • B. 

      False

  • 26. 
    Select all the factors that influence the blood-brain barrier.
    • A. 

      Age

    • B. 

      Breed

    • C. 

      Species

    • D. 

      Meningitis

    • E. 

      General anesthetics

    • F. 

      High doses of mercury

    • G. 

      Sex

    • H. 

      Body weight

    • I. 

      Trauma

    • J. 

      Temperament

  • 27. 
    What is biotransformation?
    • A. 

      The movement of drugs in the body across the biological membranes until the are eliminated

    • B. 

      The movement of drugs from plasma to tissues

    • C. 

      The chemical alteration of the drug by the cells

    • D. 

      The clearance of the drug from the body

  • 28. 
    Where does most biotransformation of drugs occur?
    • A. 

      In biomorphisomal proteins in the blood plasma

    • B. 

      In renal mitochondria

    • C. 

      In vesicles of the interstium

    • D. 

      In microsomes of hepatocytes

  • 29. 
    Which of the following is not a phase I metabolic reaction of biotransformation?
    • A. 

      Oxidation

    • B. 

      Reduction

    • C. 

      Hydrolysis

    • D. 

      Conjugation

  • 30. 
    Which is/ are not oxidation reaction(s)?
    • A. 

      Dehydroxylation

    • B. 

      Deamination

    • C. 

      Dealkylation

    • D. 

      Sulfuration

    • E. 

      Sulfoxide formation

    • F. 

      Addition of hydrogen to chloral hydrate

  • 31. 
    Which of the following is a microsomal conjugation?
    • A. 

      Glucuronidation

    • B. 

      Nitro reduction

    • C. 

      Acetylation

    • D. 

      Sulfate conjugation

  • 32. 
    Select all the factors that alter biotransformation.
    • A. 

      Species

    • B. 

      Breed

    • C. 

      Individual

    • D. 

      Route of administration

    • E. 

      Cumulation

    • F. 

      Drug-drug interaction

    • G. 

      Body weight

    • H. 

      Age

    • I. 

      Sex

    • J. 

      Temperament

    • K. 

      Body temperature

  • 33. 
    Cats are deficient in________.
    • A. 

      Hydroxylation and deamination

    • B. 

      Hydroxylation and dealkylation

    • C. 

      Deamination and dealkylation

    • D. 

      Desulfuration and acetylation

  • 34. 
    Which of the following animals has the least amount of plasma pseudocholinesterase
    • A. 

      Cats

    • B. 

      Dogs

    • C. 

      Cows

    • D. 

      Horses

  • 35. 
    Which of the following animals lack oxidative enzymes?
    • A. 

      Cats

    • B. 

      Dogs

    • C. 

      Cows

    • D. 

      Horses

    • E. 

      Pigs

    • F. 

      Birds

    • G. 

      Fish

  • 36. 
    Which is not an example of extensive first-pass effect?
    • A. 

      Apomorphine

    • B. 

      Lidocaine

    • C. 

      Propranolol

    • D. 

      Morphine

  • 37. 
    Which statement describes enzyme inducers incorrectly?
    • A. 

      Enzyme induction is reversible

    • B. 

      Enzyme induction reduction may lead to tolerance

    • C. 

      Enzyme induction may not lead to drug-drug interactions

    • D. 

      Nonmicrosomal enzymes are not inducible by drugs

  • 38. 
    Which is an example of an enzyme inhibitor?
    • A. 

      Rifampin

    • B. 

      Chloramphenicol

    • C. 

      Phenobarbital

    • D. 

      Benzodiazapine

  • 39. 
    Select all the physicochemical properties of drugs that will be excreted in urine
    • A. 

      Ionized

    • B. 

      Nonpolar

    • C. 

      Lipid soluble

    • D. 

      Charged

    • E. 

      Water soluble

  • 40. 
    Which statement is incorrect?
    • A. 

      The premise is false; all of the statements are correct.

    • B. 

      An increase in glomerular filtration results in an increase in excretion

    • C. 

      An increase in active tubular secretion results in an increase in excretion

    • D. 

      A decrease in tubular reabsorption results in an increase in excretion

  • 41. 
    Diogi, an 80 lb 2 year-old  male golden retriever, has a potentially toxic digoxin level of 4.5g/L.  Given that the half-life of digoxin  is 60 h, and assuming that renal function is stable and absorption is complete, for how long should the drug be stopped to allow the level to fall to 1.5g/L?
    • A. 

      < 60 h

    • B. 

      60h < 90h

    • C. 

      90h < 105h

    • D. 

      > 105 h

  • 42. 
     The volume of distribution equals _________divided by initial drug concentration.  
    • A. 

      Clearance

    • B. 

      initial drug concentration

    • C. 

      Half-life

    • D. 

      Dose

  • 43. 
    The units for clearance are:  
    • A. 

      Concentration/half-life.

    • B. 

      Dose/volume.

    • C. 

      Half-life/dose.

    • D. 

      Volume/time

  • 44. 
    F = 0.90                                   Clearance=2.9 liters/hr Volume of distribution=35 liters Half life=8.1 hr  Effective concentration = 20 micrograms/milliliter Toxic concentration=30 micrograms/milliliter Mr. Axwell brought his 154lb yorkshire pig into your clinic.  He has a presenting complaint of sneezing, lethargy, and congestion.  You determine that his poor pig has developed swine flu.  You admit him to stay overnight and order a loading dose of Drug X to be followed by continuous intravenous dosing to maintain plasma levels of Drug X at an effective concentration.  The correct loading dose of this drug to administer would be:
    • A. 

      340 mg

    • B. 

      580 mg

    • C. 

      700 mg

    • D. 

      1050 mg

  • 45. 
    Find the mean, median, mode, and population variance of the following data: 35 45 30 35 40 25
    • A. 

      35,35, 35, and 35 respectively

    • B. 

      35, 35, 35, and 42 respectively

    • C. 

      42, 35, 35, and 35 respectively

    • D. 

      35, 35, 42, and 35 respectively

    • E. 

      35, 25, 35, and 30 respectively

  • 46. 
    A histogram represents data at the ordinal level of measurement, whereas a bar graph represents data at the interval level of measurement
    • A. 

      True

    • B. 

      False