Test Your Knowledge About A Fluoroquinolone
answer These Questions To Find Out How Much You Know About Besifloxacin.
9 Questions
| Total Attempts: 581
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Questions and Answers
- 1.The besifloxacin molecule has been modified from what basic molecular structure to increase in vitro potency against and minimize resistance of bacterial targets?1-3Clinical significance of these in vitro data has not been established.In vitro studies demonstrated cross-resistance between BESIVANCE® and some fluoroquinolones. In vitro resistance to BESIVANCE develops via multiple-step mutations and occurs at a general frequency of <3.3x 10-10 for Staphylococcus aureus and <7 x 10-10 for Streptococcus pneumoniae.
- A.
Quinolone
- B.
Aminoglycoside
- C.
Macrolide
- 2.The addition of an N1 cyclopropyl moiety to the basic quinolone structure increased bactericidal activity by what mechanism?4Clinical significance of these in vitro data has not been established.
- A.
Binding to cleaved DNA only
- B.
Binding to DNA gyrase only
- C.
Binding to the enzyme-DNA pocket
- 3.Which 2 halogens contribute to the potency and broad spectrum efficacy of besifloxacin®?3,5Clinical significance of these in vitro data has not been established.
- A.
Chlorine and bromine
- B.
Bromine and fluorine
- C.
Chlorine and fluorine
- 4.By what factor is the inhibition of DNA gyrase increased when a fluorine molecule is added to the C6 position of the basic quinolone structure?1Clinical significance of these in vitro data has not been established.
- A.
2X
- B.
5X
- C.
10X
- 5.Besifloxacin contains a C6 fluorine molecule, which improves activity against which bacterial type?1Clinical significance of these in vitro data has not been established.
- A.
Gram-positive bacteria
- B.
Gram-negative bacteria
- C.
Both gram-negative and gram-positive bacteria
- 6.To which position was a chlorine molecule added to make BESIVANCE® a chlorofluoroquinolone with increased potency?3Clinical significance of these in vitro data has not been established.
- A.
C8
- B.
C9
- C.
C10
- 7.BESIVANCE® is indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of which bacterial species?6BESIVANCE® (besifloxacin ophthalmic suspension) 0.6% is a quinolone antimicrobial indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following bacteria:Aerococcus viridans*, CDC coryneform group G, Corynebacterium pseudodiphtheriticum*, Corynebacterium striatum*, Haemophilus influenzae, Moraxella catarrhalis*, Pseudomonas aeruginosa*, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis*, Staphylococcus lugdunensis*, Staphylococcus warneri*, Streptococcus mitis group, Streptococcus oralis, Streptococcus pneumoniae, Streptococcus salivarus**Efficacy for this organism was studied in fewer than 10 infections.
- A.
Aerococcus viridans, Pseudomonas aeruginosa, and Moraxella catarrhalis
- B.
Staphylococcus aureus and Staphylococcus epidermidis
- C.
Both choices A and B, among others. Please see prescribing information for complete indication.
- 8.The dually halogenated structure of BESIVANCE® confers potent and balanced inhibition of which 2 bacterial enzymes?6,9,10Clinical significance of these in vitro data has not been established.In vitro studies demonstrated cross-resistance between BESIVANCE® and some fluoroquinolones. In vitro resistance to BESIVANCE® develops via multiple-step mutations and occurs at a general frequency of <3.3x 10-10 for Staphylococcus aureus and <7 x 10-10 for Streptococcus pneumoniae.
- A.
DNA polymerase I and DNA ligase
- B.
Helicase and primase
- C.
DNA gyrase and topoisomerase IV
- 9.At minimum, how many mutations must a bacterium accumulate to develop significant levels of resistance to BESIVANCE®?11Clinical significance of these in vitro data has not been established.In vitro studies demonstrated cross-resistance between BESIVANCE® and some fluoroquinolones. In vitro resistance to BESIVANCE® develops via multiple-step mutations and occurs at a general frequency of <3.3x 10-10 for Staphylococcus aureus and <7 x 10-10 for Streptococcus pneumoniae.
- A.
1
- B.
2
- C.
3
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