Respiratory System: Disorders of Ventilation&Gas Exchange

Class lecture .  Respiratory system: disorders of Ventilation and Gas Exchange

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Cards In This Set

Front Back
Pleural effusion is an abnormal collection of fluid in the pleural cavity. Results in lung compression and dysnea
Causes- increased capillary pressure (CHF), Increased capillary permeabilty(inflammation) hypoalbuminemia,
(liver damage) impaired lymphatic drainage damage(cancer)
Pleural effusion
Atelectasis is the incomplete expansion of a lung or portion of a lung. Causes airway obstruction, lung compression
( pneumothorax or pleural effusion). Increased recoil of the lung due to loss of pulmonary surfactant
Pneumothorax is air in pleural cavity. Partial or complete lung collapse. causes: may be spontaneous or due to trauma
Obstructive lung diease
Bronchial Asthma
Hyperreactive airways reacts to various stimuli and produce, and produce episodic bronchoconstriction
Atopic (Allergic, Extrinsic) Asthma Inhaled allergens produce a type 1
Hypersensitivity response with increased eosinophils seen in sputum and peripheral blood
Nonatopic (intrinsic) Asthma
Bronchoconstriction is triggered by infections , cold and air pollutants, typically in the middle aged adults
Chronic Bronchitis- chronic irritation of airways ( smoking, air pollution) complicated by repeated
Infections leads to a persistant cough with sputum production for at least 3 months in at least 2 consecutive years.
There is hypersecretion of mucus from hypertrophied submucosal glands with goblet cell hyperplasia
Chronic bronchitis
Emphysema
Destruction of the normal pulmonary acinar structure leads to dilation of distal airspaces.
Centrilobular (emphysema) (Centriacinar)
Predominanantly the respiratory bronchioles of the proximal acinar structure are affected,sparing distal aleveoli
Mostly seen in smokers. upper lung fields are predominantly involved, most common in smokers
Centrilobular (Centriacinar)
Paniobular (Panacinar) (emphysema) All portions of the acinus are involved
Lower lung fields are predominantly involved. Can occur in association with alpah-1 antitrypsin deficiency
Paraseptal (irregular) (emphysema)
Focal scarring. often subpleural, results in dilation of airspaces.
Bronchiectasis
Chronic infection leads to destruction and dilation of bronchi