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What kind of "agent" is a muscarinic agonist?
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Parasympathomimetic agents
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What kind of "agent" is a muscarinic antagonist?
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Anticholinergic drug
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M1 muscarinic receptors affect what?
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The CNS and salivary glands
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T/F: M1 muscarinic receptors when activated enhance CNS activity and salivary production
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TRUE
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T/F: M1 muscarinic receptors when blocked cause dryness and confusion
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TRUE
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What occurs with the Heart Rate with the activation of M2 receptors?
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Heart rate decreases
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T/F: Blocking the activation of M2 receptors will cause increased Heart Rate.
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TRUE
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M2 muscarinic receptors affect what?
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The Heart
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M3 muscarinic receptors affect what?
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Salivary glands, GI smooth muscle, iris sphincter...
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T/F: Activation of M3 will cause muscle relaxation
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FALSE
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Blocking the M3 receptor will induce muscle relaxation
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TRUE
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What are the S&S of cholinergic drugs?
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* abdominal cramps, * diarrhea, * excessive mouth secretions, * difficulty breathing, * muscle weakness
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What is an example of a muscarinic agonist?
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Bethanechol
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What is the MOA of bethanechol?
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Direct acting muscarinic agonist (binds reversibly to muscarinic cholinergic receptors causing activation)
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What is the use of bethanechol?
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Indicated for urinary retention, GERD, GI paralysis, post-op distention, NOT for use with a physical UT obstruction
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