MicroImmunology Test 1:Intro to Immunology and the Complement System

These are flashcards for Test 1 Section 1. Dr Hall Fall 08

25 cards   |   Total Attempts: 182
  

Cards In This Set

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What is innate immunity?
*Universal to populations *Non-specific *Predominate in early stages *takes only hours for max effect
What innate immunity cells?
*neutrophils *monocytes *macrophages *NK cells * Eosinophils
What is adaptative immunity?
*Predominate in the middle and late stages;No physical barriers;Improves during the course of the immune response;Takes days to weeks for max effect.
What cells are adaptative immunity?
B and T lymphoctyes
What are the four main functions of the complement system in the immune response?
1.Lyse cells, bacteria, and viruses via membrane attack complex (MHC)
What are the four main functions of the complement system in the immune response?
2.Opsonization (coating) of foreign cells, bacteria, viruses, fungi, etc. for phagoctyes
What are the four main functions of the complement system in the immune response?
3. Generation of peptide fragments (C3a, C5a) to attract leukocytes to sites of infection (chemotaxis)
What are the four main functions of the complement system in the immune response?
4.Clearance of immune complexes from the circulation.
What activates the classic pathway of the complement system?
Activated by antigen-antibody complexes(IgM, IgG)
What activates the alternative pathway of the complement system?
Activated by bacteria, yeast, parasites, virally infected cells or soluble immune complexes (not antibody mediated)
What activates the lectin pathway of the complement system?
Acute phase reactants that bind to bacteria. Proteins that recognize and bind to specific carbohydrate target.
What is the C-reactive protein (CRP)?
A major acute-phase protein made by the liver for tissue damage that binds to C-polysaccharide cell wall component found on a var of bact and fungi.
What is Mannose Binding Lectin (MBL)?
Binds to mannose residues on gylcoproteins or carbohydrates on the surface of bacteria and fungi then activates complement system.
What do all pathways of the complement system try to do?
They all try to activate and produce C3b to the activator or pathogen.
What is a clinical consequence of complement deficiencies?
If someone is deficient in C3, this would increase the chance of death.