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Cards In This Set
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What does connective tissue originate from?
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Mesenchyme (mesoderm)
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Semi-fluid ground substance containing reticular fibers
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Matrix
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Cells found in CT
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Fibroblasts, chondrocytes, osteocytes, adipocytes
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Background material within which all other CT elements are embedded - contributes to consistency of ECM
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Ground substance
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Components of ground substance
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Mostly water that is stabilized by complex of proteoglycans, glycosaminoglycans, and glycoproteins
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Synthesize carbohydrates of ground substance
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Fibroblasts
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Negatively charged polysaccharide chains made of repeating disaccharide units; its rigidity provides structural framework for CT cells
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Glycosaminoglycans
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"gel forming" in water because of negative charge and carb --> "Jello" effect, cushioning function and avenue for diffusion
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Glycosaminoglycan
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Dominant glycosaminoglycan in CT that acts as backbone for assembly of other GAGs
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Hyaluronic acid
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Chondroitin sulfate, dermatan sulfate, keratin sulfate, heparin sulfate
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Glycosaminoglycans
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Consists of GAGs that entend perpendicularly from protein core (like pine trees)
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Proteoglycans
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Responsible for highly viscous nature of ground substance
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GAGs
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Aggrecan (hydrate ECM of cartilage) and decorin (orient fibers in collagen genesis)
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Extracellular proteoglycans
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Proteoglycans that attach to cell membranes and aid in cell to cell or cell to ECM interactions are called...
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Transmembrane proteoglycans
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Large proteins invovled in cell adhesion - stabilize ECM, facilitate cell movement in ECM, aid in cell proliferation and differentiation
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Glycoproteins
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