Ch 8 Minerals: Visualizing Nutrition

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Ch 8 Minerals: Visualizing Nutrition

FSHN 185 Minerals Flashcards.

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Mineral Bioavailability
Decrease: F_____ p______ Ox______
               EX: calcium and iron
               Ex: vitamin C and iron
Animal product sources _______________
Decrease: Fiber and phytate, Oxalates
Mineral-mineral interactions
               EX: calcium and iron
Vitamin-mineral interactions
               Ex: vitamin C and iron
Animal product sources generally best absorbed
Minerals Most Likely to be Deficient in N. America

Major functions of minerals F E A S BL
Fluid balance
Energy Metabolism
Antioxidants Structure (bones)
Blood components
Fluid Balance: Four components? S C P P What  are Sources of each? Purpose of each?
Table salt (NaCl):40% sodium, 60% chloride
Major (+) ion, extracellular fluid
Table salt
Major (-) ion, extracellular fluid
Fruits, vegetables, milk, grains, meats, dried beans
Major (+) ion, intracellular fluid
Dairy and meats
20-30% from food additives
Soda contains phosphoric acid
Difficult to limit intake
Food Manufactures Vs. Home Cooked:
How does sodium chloride get into our food? (%)
Where does it come from?
~15% added by individuals
~10% naturally occurring in foods
~ 75% added by food manufacturers
What minerals contribute to Structure (Bones)? What are they found in?
Makes up 40% of all the mineral present in the body
Has many functions in addition to bones
Plant products: legumes, seeds, nuts, whole grains, vegetables
Toothpaste, tea
Calcium / Bone Mass Facts: Peak mass age? Loss begins age? Major bone mass loss called? What is is? Who / what increased risk?
Peak bone mass: age 20-30
Bone loss begins: age 30-40
Significant loss at menopause
Poor bone structure
High risk: female, small frame, old age, low calcium intake, smoking, ED
Calcium Absorption: Enhancers / Inhibitors
Best source of calcium?
Vitamin D, stomach acid
Phytates, oxalates, tannins
Dairy is best source of Calcium
Vegetarianism and calcium: challenges & tips
Difficult to ____  ____ without ____.
Some _____ sources are poorly absorbed
Choose ________foods
Dairy ___________
T_____  (some types)
Some RTE ______, _______
Some green ________
Difficult to meet needs without dairy
Some plant sources are poorly absorbed
Choose fortified foods
Dairy substitutes
Tofu (some types)
Some RTE cereals, snacks
Some green vegetables
Sulfur controls _____ base balance. Source? Component of?
Acid-base balance
Source: food proteins
Component of body protein
Two types of bones:
Cortical or compact bone
Trabecular or spongy bone
Bone is composed of:
a protein frame work, or matrix, hardened by deposits of minerals

___________  is the most abundant protein
_____________  is the calcium-phosphorus crystal
Collagen is the most abundant protein
Hydroxyapatite is the calcium-phosphorus crystal
Two types of iron in the diet? Each comes from where?
Heme iron: part of hemoglobin and myoglobin in animal products. Heme iron is absorbed more efficiently and less affected by other dietary factors
Nonheme iron: in plant  foods and released from cooking utensils
Map basic chemical structure of heme iron.

Fe chem structure
Map path of HEME iron in digestive track

HEME path: a HEME group is absorbed in small intestine (lumen) at Mucosal wall. Breaks down into "breakdown products" and Fe2+.... Fe2+ joins Ferritin within the mucosal cell to become Fe3+. The Fe3+ joins with a CU-containing protein and moves into the blood stream.  Fe3+ joins Transferrin in the blood stream. From blood stream, it goes bone marrow (red blood cells or hemoglogin), and body cells (myoglobin). Some Fe3+ goes to liver where it can pick up Ferritin because the liver stores iron from "old" red blood cells. Iron is also lost with blood loss.
Absorption of nonheme iron is affected by many factors

Fiber, phytates, tannins, and oxalates bind to iron in the GI tract and reduce absorption
The presence of other minerals in a meal can decrease iron absorption (esp. calcium)
Map path of NON-HEME iron in digestive track
Non-heme iron enters the mucosal cell as Fe2+. Some is lost as mucosal cell is sloughed off. Some is retained and joins Ferritin to become Fe3+.  Fe3+ joins with a CU-containing protein and enters the blood stream. In the blood stream, it joins with Transferrin and serves all the same processes as HEME iron (bone marrow - rbc, body cells, liver.
Regulation of iron transportation
*Absorbed iron is bound to storage protein ferritin or picked up by the transport protein transferrin
*The transferrin-iron complex binds to transferrin receptors to deliver iron into cells
*The transferrin receptor gene is regulated based on amount of body storage iron
Iron stores and Iron losses:
Iron stores
In ferritin in the liver, spleen, and bone marrow
High levels of liver ferritin can be converted to hemosiderin

Iron losses
The body recycles iron
Blood loss and shedding of cells from intestine, skin, and urinary tract are major reasons iron is lost in healthy individuals  

Functions of iron O N C E
*Delivery of OXYGENto cells via two oxygen-carrying proteins hemoglobin and myoglobin
*NEUROtransmitter synthesis in brain
*Normal immune function and drug metabolism*CO-factor for enzymes that protect cells from oxidative damage. A cofactor for many other enzymes  *ENERGY production

Iron is in 3 locations in the body: The iron stores, the plasma and the red blood cells. In what order does iron "disappear" from these locations when iron intake is inadequate?
First, the iron stores get low. Second, iron is diminished in the plasma and you have low levels of circulating iron. Last, Iron begins to be missing from the red blood cells and you have iron deficiency anemia - sick red blood cells.
Symptoms of Iron deficiency anemia
Fatigue and weakness
Cannot maintain body temperature
Change in mental/emotional state
Prone to infection
Adverse pregnancy outcomes
Impaired development
Pica? Ice crunch craving

Groups at most risk for Iron deficiency anemia?
Infants, children, adolescents
Women of reproductive age
Pregnant women
Iron toxicity: acute v. chronic
Acute toxicity
Ingestion of a single large dose at one time
Chronic toxicity
*Caused by iron overload
*Most common cause is hemochromatosis
*Overconsumption of iron supplements or diet high in absorbable iron can increase iron stores
*Excess free iron promotes formation of free radicals and causes cell damage

Iron deficiency and iron excess damage ______________
and _____________  _____ in rats.
Iron deficiency and iron excess damage mitochondria
and mitochondrial DNA in rats.
Meeting Iron need: you must consider the TOTAL diet to avoid excess or under consumption:
Best sources: _______
Bioavailability from heme sources ___________
" from non-heme sources ____________
Bioavailability goes ______ with low iron status
non-heme iron absorption is _______ by vitamin C
Take ___________ is you are in an at risk group.

Best sources are red meats and organ meats (heme)
Bioavailability for heme sources: 15 to 35% (absorbed)
Bioavailability for nonheme sources:
    spinach & rice: 1%,
    beans and grains: 4 to 7%
    (bioavailability unknown for most non-heme iron sources
Bioavailability  ↑  with low iron status
Nonheme iron absorption enhanced by vitamin C
 Supplements recommended for groups at risk
_______ for adult men and _________ for adult women

Vegetarians – ________  for adult men and _______ for adult women

Pregnancy –_______   , _____ for pregnant vegetarian

8 mg/day for adult men and 18 mg/day for adult women

Vegetarians – 14 mg/day for adult men and 33 mg/day for adult women

Pregnancy – 27 mg/day
50 mg/day for pregnant vegetarian
The most ______intracellular trace element
Involved in functions of over 300 _____
Important for _____ and repair of ______
The most abundant intracellular trace element
Involved in functions of over 300 enzymes
Important for growth and repair of tissue
Zinc from  _________     _____ is better absorbed because zinc in plant sources is often bound by ________
Zinc from animal food is better absorbed because zinc in plant sources is often bound by phytates
Enzyme ______
Synthesis of ______
Interferes with _____ metabolism
__ symptoms

Enzyme cofactor
Synthesis of DNA/RNA
Interferes with copper metabolism
GI symptoms

Zinc Deficiency =

Poor growth
Inadequate sexual development
Most common in underdeveloped countries
3 Sources of Zinc

Animal products
Fortified cereals
Zinc RDA: Men, women and vegetarians?
11 mg/day for men
8 mg/day for women (11 mg/day during pregnancy)
Vegetarians – require ~ 50% more

Iodine function:
Main component of Thyroid hormones
Regulates growth and metabolism
Iodine deficiency causes _____ and ______.
Iodine deficiency is the most well documented ____ deficiency.
Goiter- enlargement of thyroid
Cretinism- stunting of fetal growth and mental development
Most well documented causal deficiency

Source of iodine?
Major source = Iodized salt
Also found in seafood and
Foods grown in soil with adequate iodine

Other minerals which function as cofactors are:
(these are important minerals, but we don't have to know all about them - mostly just that they matter).
Copper (Legumes, whole grains, nuts, shellfish, seeds)
Chromium (Egg yolks, whole grains)
Manganese (Nuts, oats, legumes)
Molybdenum (Legumes, grains, nuts)
Selenium (Meat, fish, whole grains and plant sources  - grown in selenium rich soil)

Fluoride: function and deficiency?
Reduces acid production by mouth bacteria
Improves tooth and bone strength
Tooth decay
Toxicities in:
Fluoride (3x RDA)
Tooth ______ during development
Calcium (2x RDA)
Kidney _____, calcification of _______
Iron (>>3x RDA; UL = 45 mg)
__ upset, ____ damage
Zinc (4-5x RDA)
Reduced _________ absorption
Selenium (7x RDA)
Hair ____, nausea, _____
Fluoride (3x RDA)
Tooth mottling during development
Calcium (2x RDA)
Kidney stones, calcification of tissues
Iron (>>3x RDA; UL = 45 mg)
GI upset, liver damage
Zinc (4-5x RDA)
Reduced copper absorption
Selenium (7x RDA)
Hair loss, nausea, vomiting

4 Contaminant Minerals:
Their sources?
Lead (Pb)
Cadmium (Cd)
Mercury (Hg)
Arsenic (As)

Often in nonfood sources, environmental contamination (water), fish and other marine food

Supplements are ____ necessary if you are consuming a balanced diet. What four situation are the recommended in?
Food allergy/intolerance
Low kcal intake (esp elderly)

The bioavialability of supplements may be poor because of these two factors:
Also, this type of dose may be harmful:
Vitamin-vitamin interactions
Mineral-mineral interactions
In General:*
________ increases blood pressure ( _____ retention leads to increased blood volume
_________ lowers blood pressure

In General:*
Sodium increases blood pressure (Fluid retention leads to increased blood volume)
Potassium lowers blood pressure

Name one mineral present in the following hamburger components:
Whole wheat bun
Romaine lettuce (dark green leaf)
Ground beef patty
Whole wheat bun
Romaine lettuce (dark green leaf)
Ground beef patty
Which minerals are major minerals?
Which mineral is most abundant in the body?
Which minerals function in/as…
*Fluid balance?
*Blood components?
*Energy metabolism?

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What are good sources of…
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