Bio Ch. 4 Agonists and Antagonists

Bio psychology ch.4 

65 cards   |   Total Attempts: 182
  

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Amount of neurotransmitters
Many substances are being considered as neurotransmitters and the number will continue to grow
Major Neurotransmitter Families
Acetylcholines, monoamines, amino acid transmitters, peptides. Each transmitter is produced by a defined biosynthesis process
What are potential steps in neuropharmacological compounds
Each step in synaptic transformation from axonal transport to postynaptic effects
What is the amino acid precursor for Achetylcholine
Choline and acetyl coenzyme A
What drives conversion of choline into Acetylcholine
Choline acetyltransferase
What receptors does ACH bind to?
Muscarinic receptors or nicotinic receptors
Nicotonic receptors
ACH are iontropic receptors and are found in the skeletal muscle. Because they are iontropic they are ligand gated which means they will act faster and not last as long. EPSP's
Muscarinic receptors
ACH are metabotropic receptors and are found in the PNS and CNS. Metabotropic takes longer and last longer which is better for learning and memory processes. IPSP.
Where is ACH heavily located in the brain?
Nucleus Basilis and sends projections to cortex and limbic regions
Where and what is ACH broken down by?
In the synapse by Acetylcholinesterase
Which neurotransmitters have similar biochemical pathways?
NE and DA
The amino acid tyrosine is converted to...
L-Dopa by tyrosine hydroxylase
For dopamine...what converts L-Dopa to dopamine?
Dopa-decaryboxylase
For NE what converts L-Dopa into NE?
Dopamine-beta-hydroxylase
What are DA and NE deactivated by?
Reuptake and MAO (monoamine oxidase)