Acromegaly is a disorder that results from a surplus of growth hormone after the growth plates have closed. The initial symptom is typically enlargement of hands and feet. There may be an overgrowth of the forehead, jaw, and nose.

Other symptoms may include joint pain, thicker skin, deepening of the voice, headaches, and problems with vision. Acromegaly may also cause changes in the shape of the face, such as a protruding lower jaw and brow, enlarged lower jaw and brow, and enlarged nose, thickened lips, and wider spacing between your fatigue and muscle weakness.