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Which of the following would most likely be found on a biopsy of this man’s kidney? A 43-y/o man has had type 1 diabetes mellitus for 30 years. He uses insulin to treat his diabetes, but his blood glucose levels are poorly controlled. Over the years, he has developed painful peripheral neuropathy and a nonhealing diabetic foot ulcer. Recently he has experienced increased urinary frequency, which prompted his visit to the physician. His temperature is 37.6° C (99.7° F), blood pressure is 155/95 mm Hg, heart rate is 72/min, and respiratory rate is 16/min.



A. Crescent-shaped lesions in the glomeruli
B. Nodular glomerular changes
C. The proliferation of the mesangial membranes
D. Segmental sclerosis and hyaline casts
E. Tram-track appearance on light microscopy

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Step 1 First Aid Renal System prt 2
Asked by CRUZ, Last updated: Mar 11, 2020

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3 Answers

C.Charlotte

C.Charlotte

Answered Feb 10, 2020

The production of mesangial membranes is generally one of the characteristics of uncontrolled diabetes. This gentleman has many of the common symptoms, including changes in urination. Over the years, he has acquired painful peripheral neuropathy. Mesangial cells are special cells that reside in the kidney. Together, they make up the mesangium of the glomerulus.

Because of the peripheral neuropathy, it causes glomerular changes, which would be discovered from the abundance of mesangial membranes on a biopsy. People with diabetes are at a higher possibility for a non-healing diabetic foot ulcer, which is a potentially life-threatening consequence of having diabetes. If left untreated, a possible severe infection might result in amputation.

 

Amla Amelia

Amla Amelia

Answered Feb 07, 2020

The correct answer to this question is B, Nodular glomerular changes. Diagnostic tests are vital to treating diabetic nephropathy. It helps control and prevents the disease from progressing. Answer A, Crescent-shaped lesions in the glomeruli, is incorrect because of glomerulonephritis us a rapid renal disease. It takes anywhere from weeks to months for renal failure to occur.

It is joined by damage to the capillary and changes in the bowman space. C is incorrect because membranoproliferative glomerulonephritis is not a common disorder. When it does occur, it normally affects young individuals. D is incorrect because focal segmental glomerulosclerosis occurs in African-American men. Lastly, E is incorrect because membranoproliferative glomerulonephritis is due to interpositions that occur in the capillary wall.

 

John Smith

John Smith

Answered Sep 09, 2016

Nodular glomerular changes-the correct answer is b. in diabetic nephropathy, diagnostic tests are important in the treatment and control of the progression of the disease. the histologic morphology is characterized by an increase in mesangial matrix by marked nodular accumulations known as kimmelstiel- wilson nodules and diffuse glomerulosclerosis.answer a is incorrect. rapidly progressive (crescentic) glomerulonephritis is a renal disease that has a rapid course (weeks to months) to renal failure. it is characterized by extensive capillary damage that leads to accumulation of cells and fibrinous changes in bowmans space, leading to the characteristic crescent seen on biopsy.answer c is incorrect. membranoproliferative glomerulonephritis is an uncommon autoimmune renal disorder that normally affects young individuals (830 years of age). the diagnosis is based on a histologic presentation that includes mesangial proliferation, thickening of the peripheral capillary walls by suben- dothelial immune deposits, and mesangial interposition into the capillary wall, giving rise to a tram-track appearance on light microscopy.answer d is incorrect. focal segmental glomerulosclerosis is a nephrotic disease and generally presents in young, hypertensive african- american males (obesity and hiv-positive status are also risk factors).the name of the disease describes the pattern of glomerular damage, which is glomerular sclerosis (obliteration of capillary lumen) with focal patterns (some glomeruli affected) and segmental patterns (only parts of glomerulus).answer e is incorrect. membranoproliferative glomerulonephritis is characterized by a tramtrack appearance on light microscopy due to mesangial interposition into the capillary wall.
 

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