Which of the following is the inheritance pattern of this condition? - ProProfs Discuss
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Which of the following is the inheritance pattern of this condition? A 27-year-old man goes to the doctor for an annual physical examination. On rectal examination, masses are palpated. The patient is referred for a colonoscopy, which reveals adenomatous polyps located diffusely throughout the colon. When asked about his family history, the patient states that his father passed away from colon cancer. A diagnosis of familial adenomatous polyposis is suspected, and the patient asks how he got this.



A. Autosomal dominant
B. Autosomal recessive
C. Autosomal trisomy
D. Sex chromosome abnormality
E. X-linked recessive
Asked by Katherine, Last updated: Feb 10, 2020

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3 Answers

C.Charlotte

C.Charlotte

Answered Feb 10, 2020

Autosomal dominant is one of a plethora of ways that a trait or disorder can be passed down through families. It establishes a pattern of inheritance in which an affected person has one duplicate of an abnormal gene and one normal gene on a pair of autosomal chromosomes.

The rule of autosomal dominant disease is that if you receive the abnormal gene from only one parent, you can get the disease. Usually, one of the parents might also have the disease. When a condition, trait, or disease is inherited, it depends on the type of chromosome that is affected (nonsex or sex chromosome). It also depends upon whether or not the trait is dominant or recessive.

 

Amla Amelia

Amla Amelia

Answered Feb 07, 2020

The correct answer to this question is A, Autosomal dominant. Familial adenomatous polyposis, also known as FAP, is a conditional that is autosomal dominant. The condition is characterized by the germline mutation of chromosome 5. This mutation specifically occurs at the adenomatous polyposis coli locus. The APC gene has tumor-suppressive effects.

The loss of it is more associated with colon cancers. Those that develop Familial adenomatous polyposis (FAP) have a high risk of developing conditions such as liver neoplasm, gastric neoplasm, and thyroid neoplasm. The other answers are incorrect because they are associated with other conditions. For example, autosomal recessive conditions are related to sickle cell anemia and cystic fibrosis.

 

John Smith

John Smith

Answered Sep 09, 2016

Autosomal dominant-the correct answer is a. familial adenomatous polyposis (fap) is an autosomal dominant condition characterized by a germline mutation on chromosome 5, specifically at the adenomatous polypsis coli (apc) locus. the apcgene is thought to have tumor suppressive effects, and its loss is associated with more than colonic cancers. patients with fap are at increased risk for developing duodenal, gastric, liver, thyroid, and central nervous system neoplasmsanswer b is incorrect. examples of autosomal recessive conditions include cystic fibrosis, sickle cell anemia, and hemochromatosisanswer c is incorrect. examples of autosomal trisomy conditions include downs syndrome (trisomy 21), edwards syndrome (trisomy 18), and pataus syndrome (trisomy 13)answer d is incorrect. examples of conditions related to sex chromosome abnormalities include klinefelters syndrome (xxy), turners syndrome (xo), and double-y males (xyy)answer e is incorrect. examples of x-linked recessive conditions include fragile x syndrome, hemophilia a and b, glucose-6-phosphate dehydrogenase deficiency, and lesch-nyhan syndrome.
 

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