Which of the following is the most likely explanation for the cardiac - ProProfs Discuss
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Which of the following is the most likely explanation for the cardiac arrest?
A healthy 21-year-old man dies suddenly of cardiac arrest after snorting cocaine.



A. Acetylcholinesterase
B. A2-Adrenergic receptors
C. B2-Adrenergic receptors
D. Monoamine oxidase
E. Muscarinic receptors
F. Norepinephrine reuptake
Asked by Elston, Last updated: Sep 12, 2018

This question is part of

NBME 13 section 1 (qst 1-50)

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3 Answers

John Adney

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marianjacks

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John Smith

John Smith

Answered on Sep 09, 2016

Norepinephrine reuptake-cardiovascular effects the major cardiovascular effects of cocaine appear to be caused by the inhibition of norepinephrine reuptake into the synaptic cleft by sympathetic neurons [2]. since reuptake is the major mechanism by which neurotransmitters are removed from active receptor sites, this inhibition results in potentiation of the response to sympathetic stimulation of innervated organs and to infused catecholamine. cocaine may also enhance the release of catecholamines from central and peripheral stores [4]. the ensuing sympathomimetic actions (increased myocardial inotropy, heart rate, systemic blood pressure, and coronary artery constriction) are mediated by stimulation of the alpha- and beta adrenergic receptors and result in increased myocardial oxygen demand. (uptodate.com)
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