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Which of the following substance's concentration will most likely be higher in the effluent from the left renal vein than that from the right renal vein?
During an experiment, a cuff occluder is placed on the left renal artery of a normal rate and inflated to cause a 90% decrease in the cross-sectional area of the artery. A catheter is placed in the left and right renal veins to sample the effluent.



A. ADH (vasopressin)
B. Aldosterone
C. Endothelin
D. Epinephrine
E. Renin

This question is part of nbme 13 section 1 (qst 1-50)

Asked by Benjamin, Last updated: Aug 10, 2020

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John Smith

John Smith

Answered Sep 09, 2016

Renin-answer: e) the test is simulating ras (renal artery stenosis). and the question is addressing your understanding of the raas. juxtaglomerular (jg) cells associated with the afferent arteriole entering the renal glomerulus are the primary site of renin storage and release in the body. a reduction in afferent arteriole pressure (kidney thinks you are hypotensive - less blood going to kidney) causes the release of renin from the jg cells, whereas increased pressure inhibits renin release. so, in this scenario the renin will be increased leaving the efferent of the left kidney as that is the kidney affected by ras. a) adh is released from the posterior pituitary in response to increased renin and increases fluid retention. b) aldosterone released from the adrenal cortex is caused by increase renin. c) endothelin (et-1) is used to control local smooth muscle constriction endothelial cells upregulate et-1 in response to hypoxia, oxidized ldl, pro-inflammatory cytokines, and bacterial toxins d) epinephrine is a sympathetic response and is produced by chromaffin cells in the adrenal medulla.
 

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