Which of the following explains the pathophysiology of type I - ProProfs Discuss
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Which of the following explains the pathophysiology of type I familial dyslipidemia?



A. Apolipoprotein E defi ciency
B. LDL cholesterol receptor defi ciency
C. Lipoprotein lipase defi ciency
D. VLDL cholesterol clearance defi ciency
E. VLDL cholesterol overproduction

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Step 1 First Aid Biochemistry prt 1
Asked by Keira, Last updated: Jul 02, 2020

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3 Answers

C.Charlotte

C.Charlotte

Answered Feb 10, 2020

VLDL cholesterol overproduction. Dyslipidemia consists of a group of disorders that are demonstrated by variations in plasma lipids or lipoproteins. These are cholesterol and triglycerides. VDL contains more triglycerides than LDL, which has more cholesterol. VDL, which stands for very low - density lipoprotein, is the bad cholesterol. Having too much of either one of these or both can lead to building up in your arteries.

Dyslipidemia is more likely to lead to health problems when someone possesses other cardiovascular disease factors. This disease factor can include high blood pressure and diabetes. The most common causes of dyslipidemia include both lifestyle and genetic components. This combination means that even if your genetically predisposed to dyslipidemia, you can control or alter the outcome by eating healthy foods and exercising.

 

Amla Amelia

Amla Amelia

Answered Feb 07, 2020

The correct answer to this question is C, Lipoprotein lipase deficiency. This deficiency is a genetic disorder. When this disorder occurs, the person has a defective gene for lipoprotein. When it occurs, it leads to triglycerides, which are very high. These triglycerides can cause deposits of fats under the skin, as well as stomach pain.

These instances can lead to problems for the liver and the pancreas. From there, problems to the liver and pancreas can be the cause of diabetes. Lipoprotein lipase deficiency only occurs if the child has the defective gene from both of their parents. To manage the deficiency, a person must restrict their fat diet to less than 20 g/day

 

John Smith

John Smith

Answered Sep 09, 2016

Lipoprotein lipase defi ciency-the correct answer is c. type i dyslipidemia is caused by a defi ciency of lipoprotein lipase. this enzyme exists in capillary walls of adipose and muscle tissue and cleaves triglycerides into free fatty acids and glycerol. the enzyme is activated by apolipoprotein c-ii, which is found on vldl cholesterol and chylomicrons. type i dyslipidemia is characterized by an accumulation of triglyceride-rich lipoproteins in the plasma. it can also occur with an alteration in apolipoprotein c-ii.answer a is incorrect. vldl cholesterol remnants are removed from the circulation by apolipoproteine receptors. thus, apolipoprotein e deficiency results in a decreased efficiency of that clearance and elevated vldl cholesterol, triglyceride, and cholesterol levels. dysbetalipoproteinemia often only manifests with additional factors that cause hyperlipidemia such as diabetes. xanthomas are often present.answer b is incorrect. ldl cholesterol receptor dysfunction is characteristic of familial hyperbetalipoproteinemia, also known as type ii hyperlipidemia. in these cases, plasma ldl cholesterol levels rise, which causes an increase in plasma cholesterol; triglyceride levels remain normal.answer d is incorrect. mixed hypertriglyceridemia (type v) is a dyslipidemia characterized by extremely high triglyceride levels and visibly foamy plasma. unlike type i, type v is characterized by elevated vldl cholesterol levels and is thought to be related to a vldl cholesterol clearance problem.answer e is incorrect. vldl cholesterol overproduction is another characteristic of type v dyslipidemias, as well as type iib combined hyperlipidemia.
 

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