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The most common chromosomal aberration responsible for fetal death? (more than one correct answer possible)



A. 45X
B. 47XX, +21
C. 47XY, +18
D. 47XY, +16
E. 47XX, +13
F. 45X/46XY
G. 49XXXXY

This question is part of

Block 15 Genetic Pathology
Asked by Ackerley, Last updated: Jan 27, 2020

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1 Answer

John Smith

John Smith

Answered Sep 09, 2016

45x-2. 47xy, +16-trisomy 16 is a chromosomal abnormality in which there are 3 copies of chromosome 16 rather than two. it is the most common trisomy leading to miscarriage and the second most common chromosomal cause of it, closely following x-chromosome monosomy. like most chromosomal abnormalities, trisomy 16 usually causes miscarriage in the first trimester of pregnancy. it is not possible for a child to be born alive with an extra copy of this chromosome present in all cells (called full trisomy 16). it is possible for a child to be born alive with the mosaic form despite the excellent postnatal prognosis, 99% of turner-syndrome conceptions are thought to end in spontaneous abortion or stillbirth, and as many as 15% of all spontaneous abortions have the x,o karyotype
 

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