Which of the following drugs, given locally, would be appropriate for this patient?
A 32-year-old woman presents to her gynecologist with a 4 days history of perineal
pruritus and a non-malodorous, thick, cheesy vaginal discharge. The only medication the
woman is taking is an oral contraceptive. A wet preparation of vaginal secretion shows
budding yeast cells and pseudohyphae.
A. Mebendazole B. Metronidazole C. Miconazole D. Zidovudine E. Griseofulvin F. Saquinavir
the symptoms of the patient and the lab results strongly suggest that she is suffering from
genital candidiasis, the most common opportunistic mycosis of genital tract in women taking
oral contraceptives. other predisposing factors include pregnancy, menstruation, diabetes
mellitus, and use of broad-spectrum antibiotics, corticosteroids, or immunosuppressive drugs.
budding yeast cells and pseudohyphae of candida albicans ( the most common candida
species causing candidiasis), can be detected by microscopic examination of biologic
candida albicans is sensitive to most antifungal drugs, but for genital candidiasis a topical azole
derivative (miconazole, ketoconazole, etc. ) or topical nystatin are the treatments of choice.
a, b, d) these agents are not antifungal drugs.
e, f) these antifungal drugs are not effective against candida albicans.