There are four correct answers to this question. The first is A, Amphotericin B - normocytic anemia in which the drug decreases the production of erythropoietin, which is known for causing normocytic anemia. B is also correct Griseofulvin - photosensitivity. The drug can cause reactions like photosensitivity.
The third correct answer is C, Flucytosine - myelosuppression, in which the drug Flucytosine can give one effect of anti-cancer drugs like myelosuppression. The last correct answer to this question is D, ketoconazole - menstrual irregularities. This drug can cause irregularities in a woman's menstrual cycle. E is incorrect because it is rare for nystatin to produce any effects.
Amphotericin b - normocytic anemia-2. griseofulvin - photosensitivity-3. flucytosine - myelosuppression-4. ketoconazole - menstrual irregularities-answer: abcd
amphotericin b causes nephrotoxicity that can affect up to 80% of patients the decreased
production of erythropoietin frequently leads to a normocytic anemia.
griseofulvin is an allergenic drugs that can cause many hypersensitivity reactions including
photosensitivity. flucytosine may be partially converted to 5-fluorouracil by the intestinal flora of
the host ans so can exhibit some characteristic effects of anticancer drugs like
myelosuppression (up to 13% of patients) and alopecia.
ketoconazole can affect gonadal hormone synthesis by inhibiting the cytochrome p450 system.
this can cause menstrual irregularities in women and impotence in men.
e) nystatin is given only topically or by oral route for intestinal candidiasis. in both cases the
drug is not absorbed so central adverse effects are quite unlikely.