Which of the following neurotransmitters has been implicated as a - ProProfs Discuss
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Which of the following neurotransmitters has been implicated as a cause of cell death following stroke? A 79-year-old woman complained of sharp headache in the temporal area. Fifteen minutes later she lost consciousness and was brought to the Emergency Room. A CT scan showed a diffuse brain hemorrhage and the diagnosis of a left middle cerebral artery stroke was made.



A. Acetylcholine
B. Norepinephrine
C. GABA
D. Serotonin
E. Glutamate
Asked by E.Barrington, Last updated: Jul 10, 2019

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2 Answers

John Adney

John Adney

Answered on Jan 26, 2017

A is the correct answer
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John Smith

John Smith

Answered on Sep 09, 2016

Glutamate-answer: e (katzung, pp 347, brunton, pp 332) although glutamate is essential for brain function, too much glutamate can be toxic to neurons. when blood flow to the brain tissue is impaired, mechanism of normal glutamate reuptake stops and glutamate accumulates into the synaptic cleft. this high concentration of glutamate can activate a large amount of glutamate ionotropic receptors, so triggering a huge influx of ca++ into postsynaptic cells. this intracellular high ca++ level can cause neuronal death. this property of glutamate is called excitotoxicity and can play an important role in a number of brain disorders including stroke and epilepsy. a, b, c, d) these neurotransmitters do not cause excitotoxicity.
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