The following table shows the relative activities of five new drugs, which are able to
increase the availability of specific CNS neurotransmitters into the synaptic cleft.
Examine the table and identify which one of the drugs A, B, C, D, E, is most likely to be
effective in the treatment of major obsessive-compulsive disorders. (+ represents the
degree of increased availability; - represents negligible effect)
1. c-answer: c(katzung, pp 490, koda-kimble, pp 76-37)drugs that increase the availability of serotonin in the synaptic cleft (like ssris andclomipramine) are the only first line medication treatments for obsessive compulsive disorders.the pathophysiology of these disorders seems to involve orbitofrontal-limbic-basal gangliacircuits and, after treatment with ssris, functional imaging studies have shown a normalizationof hyperactivity in areas such as the caudate, orbitofrontal lobes and cingulate cortex.a, b, d, e) (see explanation above)