A 31-year-old woman seeks evaluation in a psychiatric clinic. She reports episodic
feeling of sadness since adolescence, but she has noticed a gradual worsening in her
mood over the past three weeks. She has depressed mood most of the day, has lost
interest in any leisure activity, has difficulty sleeping, poor appetite, low energy, feeling
of guilt and recurrent though of death. Which of the following pairs of neurotransmitters
are most likely involved in the patient’s disorder?
A. Glutamate and serotonin B. Norepinephrine and glutamate C. Glutamate and acetylcholine D. Serotonin and norepinephrine E. Serotonin and acetylcholine F. Acetylcholine and norepinephrine
1. serotonin and norepinephrine-answer: d(katzung, pp 482, koda-kimble, pp 79-4)the patient has six of the symptoms that are essential features of major depression. amongthe biochemical theories of depression the strongest evidence is for an abnormality inserotonergic and noradrenergic function. this amine hypothesis of depression is supported byseveral lines of evidence including the fact that most antidepressant drugs increase theavailability of serotonin and norepinephrine in the cns.a, b, c, e, f) glutamate and acetylcholine do not seem to be involved in the pathogenesis ofdepression