A 25 year old woman was brought to the Emergency Room because of a - ProProfs
     

A 25-year-old woman was brought to the Emergency Room because of a generalized tonic-clonic seizure. Her husband stated that his wife has been suffering from epilepsy since childhood, but the seizures were only partially controlled by medication. Which of the following pairs of neurotransmitters are thought to be mainly involved in seizure disorders?



A. GABA and serotonin
B. GABA and glutamate
C. GABA and acetylcholine
D. Serotonin and glutamate
E. Serotonin and acetylcholine
F. Acetylcholine and glutamate

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Gaba and glutamate-answer: b (katzung, pp 380, golan, pp 194) epilepsy is a chronic recurrent disorder of cerebral function that may be characterized by repeated seizures. the essence of epilepsy is probably a chronic low seizure threshold which can be due to several mechanisms. a leading mechanism postulates that the cause of seizures is either the attenuation of pre and/or postsynaptic inhibition (mainly due to a genetic or postpathologic hypofunction of gaba neurons) or an increased effectiveness of excitatory synapses (mainly due to a genetic or postpathologic hyperfunction of glutamate neurons). a, c, d, e, f) (see explanation above)

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