A 32-year-old man, recently diagnosed with partial seizure, started a treatment with
felbamate, a drug that is thought to act by blocking NMDA receptors in the brain. Which
of the following systems was most likely affected by the drug?
A. Noradrenergic B. Cholinergic C. Histaminergic D. Dopaminergic E. Serotonergic F. GABAergic G. Glutamatergic
(katzung, pp 385, brunton pp 520)
glutamate is important excitatory neurotransmitter in the brain. glutamate receptors include
nmda and ampa receptors. drugs, like felbamate, that seem to act by blocking these
receptors can be used effectively as anticonvulsants.
a, b, c, d, e) these systems are not exclusively excitatory and therefore drugs affecting these
systems are not used as anticonvulsants.
g) the gabaergic system is a central inhibitory system. drugs that increase the activity of this
system (like benzodiazepines and barbiturates) are currently used as anticonvulsants.