Gaba b receptors activation leads to ipsp-2. gaba a receptors blockade leads to decreased cl- conductance-answer: cd
(katzung, pp 345, brunton pp 330)
gaba b receptors activation leads to opening of k+ channels. this causes a hyperpolarization
of the postsynaptic membrane (k+ exits from the
cell) and therefore the
production of ipsp.
gaba receptors activation directly opens cl- channels on postsynaptic membrane, so causing
an increase of cl- conductance. gaba a receptors blockade does the opposite.
a) gaba a ionotropic, gaba b receptors are metabotropic, i.e. g-
protein coupled..
b) gaba receptors do not regulate na+ channels.
e actually gaba b receptors activation leads to increased k+ conductance. gaba b receptors
blockade does the opposite.
