Which the following statements related to GABA A and GABA B receptors - ProProfs
     

Which the following statements related to GABA A and GABA B receptors are correct? (Check all that apply)



A. GABA A receptors are G-protein coupled receptors
B. GABA A receptors activation leads to increased Na+ conductance
C. GABA B receptors activation leads to IPSP
D. GABA A receptors blockade leads to decreased Cl- conductance
E. GABA B receptors blockade leads to increased K+ conductance

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Gaba b receptors activation leads to ipsp-2. gaba a receptors blockade leads to decreased cl- conductance-answer: cd (katzung, pp 345, brunton pp 330) gaba b receptors activation leads to opening of k+ channels. this causes a hyperpolarization of the postsynaptic membrane (k+ exits from the cell) and therefore the production of ipsp. gaba receptors activation directly opens cl- channels on postsynaptic membrane, so causing an increase of cl- conductance. gaba a receptors blockade does the opposite. a) gaba a ionotropic, gaba b receptors are metabotropic, i.e. g-protein coupled.. b) gaba receptors do not regulate na+ channels. e actually gaba b receptors activation leads to increased k+ conductance. gaba b receptors blockade does the opposite.

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