(katzung, pp 344, brunton pp 330)
the gabaergic system is the most important inhibitory system in the brain. gaba neurons are
short interneurons located throughout the cerebrum and cerebellum, as well as in the spinal
several cns drugs , including anxiolytics (i.e. benzodiazepines), hypnotics (i.e. zolpidem) and
anticonvulsants (i.e. barbiturates, gabapentin, vigabatrin) exert their cns depressant actions
by increasing, with different mechanisms, gaba activity.
a, b, c, d) all these systems are not purely inhibitory, but can exert excitatory or inhibitory
effects according to the receptors activated and the target tissue.
f) the endorphinergic system is an inhibitory system but it controls mainly pain circuits and is
not as ubiquitous as the gabaergic system.