Some CNS depressant drugs act on a system which is critical in - ProProfs
     

Some CNS depressant drugs act on a system which is critical in maintaining tonic inhibitory control on most other neuronal systems. Which of the following systems is the target for those drugs?



A. Noradrenergic
B. Serotonergic
C. Cholinergic
D. Dopaminergic
E. GABAergic
F. Endorphinergic

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Gabaergic-answer: e (katzung, pp 344, brunton pp 330) the gabaergic system is the most important inhibitory system in the brain. gaba neurons are short interneurons located throughout the cerebrum and cerebellum, as well as in the spinal cord. several cns drugs , including anxiolytics (i.e. benzodiazepines), hypnotics (i.e. zolpidem) and anticonvulsants (i.e. barbiturates, gabapentin, vigabatrin) exert their cns depressant actions by increasing, with different mechanisms, gaba activity. a, b, c, d) all these systems are not purely inhibitory, but can exert excitatory or inhibitory effects according to the receptors activated and the target tissue. f) the endorphinergic system is an inhibitory system but it controls mainly pain circuits and is not as ubiquitous as the gabaergic system.

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