Which of the following statements correctly matches the CNS receptor - ProProfs
     

Which of the following statements correctly matches the CNS receptor with the appropriate postreceptor mechanism? (Check all that apply)



A. M3 muscarinic - decreased NA+ conductance
B. Alpha-1 adrenergic - decreased Ca++ conductance
C. GABA A - increased Cl- conductance
D. Glycine r - decreased Cl- conductance
E. NMDA - decreased cation conductance
F. Beta-1 adrenergic - increased cAMP
G. 5-HT3 - increased cation conductance

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John Smith

John Smith

Answered on Sep 09, 2016

Gaba a - increased cl- conductance-2. beta-1 adrenergic - increased camp-3. 5-ht3 - increased cation conductance-answer: cfg (katzung, pp 345, golan pp 82) all gaba receptors are inhibitory. therefore they must hyperpolarize the postsynaptic membrane. gaba a receptors do so by increasing cl- conductance whereas gaba b receptors do the same by increasing k+ conductance. all beta receptors are metabotropic and act by increasing the synthesis of the second messenger camp. 5-ht3 receptors are mainly excitatory. therefore they must depolarize the postsynaptic membrane. by increasing cation conductance na+ can enter the cell and depolarization occurs. a) m3 receptors are mainly excitatory. a decrease in na+ conductance would cause an inhibitory effect at the postsynaptic membrane. actually activation of these receptors causes the increased synthesis of ip3/dag b) alpha-1 adrenergic receptors are excitatory. a decrease in ca++ conductance would cause an inhibitory effect at the postsynaptic membrane. actually activation of these receptors causes the increased synthesis of ip3/dag d) glycine receptors are inhibitory and cause hyperpolarization of the postsynaptic membrane by increasing, not decreasing, cl- conductance. e) nmda receptors are glutamate receptors. all glutamate receptors are excitatory and cause depolarization of the membrane by increasing, nor decreasing, cation conductance.

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