Co administration of which of the following drugs with levodopa / - ProProfs Discuss
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Co-administration of which of the following drugs with levodopa / carbidopa will increase the availability of levodopa in the brain?



A. Amantadine
B. Entacapone
C. Methyldopa
D. Benztropine
E. Bromocriptine
F. Haloperidol
Asked by Erland, Last updated: Apr 28, 2020

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John Smith

John Smith

Answered Sep 09, 2016

Entacapone-answer: b(katzung, pp 453, brunton, pp 536)entacapone belongs to the class of comt inhibitors, a new class of drugs for parkinsonism.these drugs are selective inhibitors of catechol-o-methyl-transferase (comt), the enzyme thatconverts levodopa into 3-o-methyl-dopa, a pharmacologically inactive compound. the maintherapeutic action of entacapone is to block the peripheral conversion of levodopa into 3-omethyl-dopa, so increasing both the plasma half life of levodopa as well as the fraction of eachdoses that reaches the cns.a, c, d, e, f) these drugs are not comt inhibitors.
 

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