Which of the drugs is most likely to be useful in treating - ProProfs
     

Which of the drugs is most likely to be useful in treating Parkinson’s disease? The following table shows the relative intensities of the blockade of CNS receptors of five new drugs, each of which may have potential therapeutic value.



A. Drug 1
B. Drug 2
C. Drug 3
D. Drug 4
E. Drug 5

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

drug 5-answer: e(katzung, pp 454, brunton, pp 537)drugs that block muscarinic receptors may improve tremor and rigidity of parkinsonism. in thisdisease the loss of dopaminergic neurons results in the loss of balance that normally existsbetween acetylcholine and dopamine mediated neurotransmission. it seems likely that theantimuscarinic agents work by blocking the transmission of cholinergic striatal neurons, therebyminimizing the effect of the relative increase in cholinergic sensitivity.a, b) dopaminergic blockade would exacerbate, not improve, the symptoms of parkinsonism.c, d) adrenergic and gabaergic blockade would have negligible effect on parkinsonism.

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