Which of the following drugs did the patient most likely take?
A 39-year-old man, diagnosed with tonic-clonic seizures two years ago, had been receiving a drug that exhibits a dose-dependent elimination kinetics.
A. Valproic acid B. Lamotigrine C. Phenytoin D. Topiramate E. Carbamazepine F. Gabapentin
Phenytoin-answer: cphenytoin is one of the very few drugs that exhibits first order elimination kinetics at low dosesbut switches to a zero order elimination kinetics at higher doses, that is the elimination kineticsof the drug is dose-dependent. important consequence of dose-dependent kinetics are:a) the clearance and the half life of the drug are dose-dependent.b) the time taken to reach steady state is also dose dependent, and therefore cannot bepredicted.c) a slight increase in dose can have a big effect on plasma levels, so leading to toxicity.a, b, d, e, f) all these drugs follow a first order elimination kinetics.