A 34 year old man was admitted to the psychiatric hospital because of - ProProfs
     

A 34-year-old man was admitted to the psychiatric hospital because of an acute manic attack. The man had his first manic attack at the age of 27 and had three other manic attacks since then. A diagnosis of acute mania was made and a therapy was prescribed which included a drug that acts by blocking D2 an 5HT-2 receptors in the brain. Which of the following drugs was most likely prescribed?



A. Lamotigrine
B. Clomipramine
C. Valproate
D. Olanzapine
E. Lithium
F. Trazodone

This question is part of

Block 13 Pharm Bipolar pharmacology

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Olanzapine-learning objective: explain the mechanism of action of olanzapine. answer: d an acute manic attack often requires a treatment with two or three drug combination, usually lithium plus an anticonvulsant plus an atypical neuroleptic. all neuroleptics most likely act by blocking d2 receptors in mesolimbic and mesocortical pathways. in addition they also block 5ht-2 receptors and this action may contribute to their clinical effects. atypical neuroleptics like olanzapine seems to have higher affinity for 5ht-2 receptors than for d2 receptors. a, b, c, e, f) all these drugs do not block both d2 and 5-ht2 receptors.

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