Quietapine-learning objective: describe the use of atypical antipsychotics for the maintenance therapy of bipolar disorder during pregnancy. answer: c some anticonvulsants (valproate, lamotigrine, carbamazepine) and some atypical antipsychotics (aripiprazole, olanzapine, quietapine, risperidone) have become good alternative and adjunctive treatments to lithium for maintenance therapy of bipolar disorder. among atypical antipsychotics quietapine has the lowest ratio of umbilical cord to maternal plasma concentration and does not seem to cause significant teratogenic risk to the fetus. therefore is a rational choice for maintenance therapy in a pregnant woman with bipolar disorder. a, b) valproate and carbamazepine are effective in maintenance therapy of bipolar disorder but are contraindicated during pregnancy because of a substantial teratogenic risk ( both are classified by fda in the pregnancy risk category d d, e, f) these drugs have no proven efficacy for maintenance therapy of bipolar disorder.