A 51-year-old woman was admitted to the psychiatric hospital because of depressive mood, feelings of hopelessness and suicidal ideation. The woman had a history of alternating episodes of depression and hypomania during the last eight years. An admitting diagnosis of severe bipolar depression was made an appropriated therapy was ordered. Which of the following pairs of drugs were most likely prescribed?.
A. Lamotigrine and lithium B. Amitriptyline and haloperidol C. Amitriptyline and valproate D. Lithium and ethosuximide E. Lamotigrine and ethosuximide F. Valproate and haloperidol
Lamotigrine and lithium-learning objective: describe the therapeutic uses of lamotigrine.
the history and the symptoms of the patient indicate that she is suffering from a severe
depressive episode related to the underlying bipolar disorder. when depression is severe two
(or even three drug combination) is appropriate. li+ remains a drug of choice of acute bipolar
depression with a mean response rate of about 76%. current guidelines indicate the benefit of
a combination of li+ plus an anticonvulsant (lamotigrine, valproate or carbamazepine).
b, c, d, e, f) all these combinations include at least one drug that is useless in bipolar