A 43-year-old woman recently diagnosed with major depressive disorder had started a therapy with sertraline but one month later her condition did not change appreciably and her psychiatrist decided to add a second medication (augmentation therapy). He ordered a drug with multiple mechanisms of action including an inhibition of glycogen synthase kinase-3. Which of the following drugs was most likely prescribed?
A. Bupropion B. Triiodothyronine C. Lithium D. Lamotigrine E. Buspirone F. Olanzapine
Lithium-learning objective: explain the molecular mechanisms of action of lithium.answer: cthe two main proposed mechanism of action of lithium are related to inhibition of two signaltransduction pathways, i.e. inositol signaling and glycogen synthase kinase-3 signaling theinhibition of this enzyme causes suppression of the expression of pro-apoptotic genes andincrease expression of anti-apoptotic genes. the ultimate effect is neuroprotection which couldunderlie the long term mood stabilization.a, b, d, e, f) all these drugs have been used in augmentation therapy but they do not have theabove mentioned mechanism of action.