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A 55-year-old man has experienced headaches for the first time in his life beginning 2 months ago. He comes to the emergency department following a generalized tonic-clonic seizure. MR imaging of his brain shows an ill-defined 2 cm mass in the right posterior parietal cortex. A stereotaxic biopsy of the mass microscopically shows pleomorphic cells positive for glial fibrillary acidic protein (GFAP). Molecular analysis shows abnormalities of p53 and platelet-derived growth factor-alpha (PDGF-α). He receives treatment for this lesion. Which of the following neoplasms is he most likely to develop in the future?



A. Diffuse large B cell lymphoma
B. Glioblastoma
C. Hemangioblastoma
D. Medulloblastoma
E. Pilocytic astrocytoma
Asked by Clara on Sep 09, 2016

This question is part of

Pathology Review ch 28 CNS prt 3

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Glioblastoma-(b) he initially had an infiltrating astrocytoma that is the most common primary brain neoplasm in adults, typically arising in a cerebral hemisphere. lower grade astrocytomas in adults may have a more indolent course. some of these patients go on to develop a high-grade glioma known as secondary glioblastoma. most glioblastomas arise de novo (primary glioblastoma) and have mdm2 mutations. regardless of origin, glioblastomas are aggressive and have a poor prognosis. diffuse large b cell lymphoma is the most common type of primary cns lymphoma (without evidence for disease elsewhere); some arise in immunocompromised patients. hemangioblastomas are uncommon neoplasms arising in the cerebellum, often with von hippel-lindau disease, and associated with polycythemia. medulloblastomas and pilocytic astrocytomas are usually childhood brain tumors arising in the posterior fossa. bp7 832833bp8 882pbd7 14011403pbd8 13301332
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