An infant was born at 36 weeks' gestation to a 22 year old - ProProfs
     

An infant was born at 36 weeks' gestation to a 22-year-old primigravida. A fetal screening ultrasound study at 18 weeks showed a single large cerebral ventricle and fused thalami. On physical examination at birth, the infant was small for gestational age and had multiple anomalies, including postaxial polydactyly of hands and feet, cyclopia, microcephaly, cleft lip and palate, and rocker-bottom feet. The infant died 1 hour after birth. Which of the following CNS abnormalities best explains these findings?



A. Anencephaly
B. Arnold-Chiari II malformation
C. Dandy-Walker malformation
D. Holoprosencephaly
E. Periventricular leukomalacia
F. Subdural hematoma

This question is part of

Pathology Review ch 28 CNS prt 3

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Holoprosencephaly-(d) holoprosencephaly is a midline defect in which there is absent (alobar) or partial (semilobar) cerebral hemispheric development. it can occur in trisomy 13, as in this case, with other midline defects. it also may be seen in cases of maternal diabetes mellitus. anencephaly is the absence of a fetal cranial vault, which leads to absence of most of the brain. arnold-chiari ii malformation results in a small posterior fossa, a misshapen midline cerebellum with downward displacement of the vermis, and tenting of the tectal plate. dandy-walker malformation is characterized by aplasia or hypoplasia of the cerebellar vermis, cystic enlargement of the fourth ventricle, and hydrocephalus. periventricular leukomalacia is a form of perinatal injury that is caused by hypoxic-ischemic events or infections. a subdural hematoma results from trauma. bp7 823bp8 872pbd7 1355pbd8 1285

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