Immunohistochemical aining for which of the following proteins is most likely to be positive in the inclusions in the case below?
A 60-year-old woman had problems related to movement for 5 years. Physical examination showed cogwheel rigidity of
limbs and a festinating gait, which she had difficulty initiating. Her face was expressionless. She was given levodopa, and
her condition improved. Two years later, she had difficulty performing activities of daily living and showed marked
cognitive decline. She died of aspiration pneumonia. Autopsy findings include mild cerebral atrophy and loss of substantia
nigra pigmentation. Microscopically, there is loss of pigmented neurons, and the remaining substantia nigra neurons and
cortical neurons show spheroidal, intraneuronal, cytoplasmic, and eosinophilic inclusions. Immunohistochemical staining
for which of the following proteins is most likely to be positive in these inclusions?
A. Î±-Synuclein B. Amyloid precursor protein C. Apolipoprotein E D. Huntingtin E. Presenilin F. Tau protein
Synuclein-(a) this patient has findings of dementia with lewy bodies (dlb), a form of dementia with clinical features similar to
those of alzheimer disease and idiopathic parkinson disease. mutations in the gene for -synuclein have been linked to
idiopathic parkinson disease, and lewy bodies can be found in the substantia nigra neurons, but the clinical dementia and
cortical lewy bodies point to dlb. amyloid precursor protein is encoded by a gene on chromosome 21 (perhaps
explaining early alzheimer disease in trisomy 21) and is processed to form the a amyloid of neuritic plaques in alzheimer
disease. the e4 allele of apolipoprotein e can bind a and increase the risk of alzheimer disease. huntingtin is the protein
product of the hd gene in huntington disease. presenilin 1 and 2 mutations can increase production of a and increase
the risk of early-onset alzheimer disease. tau protein is found in neurofibrillary tangles of alzheimer disease and in pick
bodies of pick disease.
bp7 844bp8 891, 895pbd7 1386, 1392pbd8 13211322