A 52 year old woman has had malaise for the past 6 months. on - ProProfs
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A 52-year-old woman has had malaise for the past 6 months. On physical examination, there are no remarkable findings. Laboratory studies show hemoglobin, 9.3 g/dL; hematocrit, 27.9%; platelet count, 549,000/mm3; and WBC count, 282,000/mm3 with 64% segmented neutrophils, 10% bands, 3% metamyelocytes, 2% myelocytes, 2% lymphocytes, 1% monocytes, 9% eosinophils, and 9% basophils. She undergoes chemotherapy. Two months later, she develops neurologic deficits with ataxia, motor weakness in the right ARM, difficulty swallowing, and sensory changes in the left leg. MRI of the brain shows irregular areas of increased attenuation in white matter of the cerebral hemispheres and the cerebellum. A stereotaxic biopsy specimen shows perivascular chronic inflammation, marked gliosis, large reactive astrocytes with bizarre nuclei, and intranuclear inclusions within oligodendroglia. What infection most likely caused these findings?



A. Cytomegalovirus
B. Herpes simplex virus
C. JC papovavirus
D. Rabies virus
E. Rubeola virus
F. West Nile virus
Asked by Ever on Sep 09, 2016

This question is part of

Pathology Review ch 28 CNS prt 3

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Jc papovavirus-(c) this patient has progressive multifocal leukoencephalopathy, which is caused by the jc papovavirus and occurs in immunocompromised individuals, including individuals with aids. the patient was treated for chronic myelogenous leukemia. cytomegalovirus infection also complicates the course of immunocompromised patients, but it causes large intranuclear inclusions, most often in endothelial cells. herpes simplex virus is uncommon, even in immunocompromised patients, and it most often produces a hemorrhagic encephalitis in temporal lobes. rabies virus produces cns excitability with convulsions, meningismus, and hydrophobia. subacute sclerosing panencephalitis is a rare complication of measles (rubeola) virus infection and leads to progressive mental decline, spasticity, and seizures. west nile virus, similar to many arboviruses, can cause a meningoencephalitis. bp7 830bp8 878879pbd7 13761377pbd8 13051306
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