A 40 year old man, who rarely had headaches, now has been - ProProfs
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A 40-year-old man, who rarely had headaches, now has been experiencing headaches for the past 6 months. He comes to the physician because of a seizure that occurred 1 day ago. On physical examination, there are no remarkable findings. MRI of the brain shows a solitary, circumscribed 3-cm mass in the right parietal centrum semiovale. The mass has small cysts and areas of calcification and hemorrhage. Neurosurgery is performed, and the mass is removed. Microscopically, the mass consists of sheets of cells with round nuclei that have granular chromatin. The cells have a moderate amount of clear cytoplasm. These cells mark with GFAP by immunohistochemical staining. The patient receives adjuvant radiation and chemotherapy, and there is no recurrence. Which of the following neoplasms was most likely present in this patient?



A. Astrocytoma
B. Diffuse large B-cell lymphoma
C. Germ cell tumor
D. Glioblastoma multiforme
E. Medulloblastoma
F. Metastatic renal cell carcinoma
G. Oligodendroglioma
Asked by Fleming on Sep 09, 2016

This question is part of

Pathology Review ch 28 CNS prt 3

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Oligodendroglioma-(g) oligodendrogliomas tend to have a better prognosis than most other glial neoplasms. astrocytomas tend to be less circumscribed. diffuse large b-cell lymphomas can occur in association with aids; they are negative for glial fibrillary acidic protein (gfap), but positive for cd19 and cd20. intracranial germ cell tumors are most likely to arise in the pineal body. glioblastomas are highly aggressive, infiltrative gliomas. medulloblastomas are posterior fossa tumors that occur in children. renal cell carcinoma has cells with clear cytoplasm, but it is not positive for gfap and often produces multiple metastases. in rare cases, removal of a solitary metastasis of renal cell carcinoma can be beneficial. bp7 833834bp8 883884pbd7 1404pbd8 13331334
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